DRUGS FOR PARKINSONISM

Question 1

Drug for Parkinson’s that acts as Dopamine precursor

Answer 1

Levodopa

Question 2

Inhibits peripheral metabolism of Levodopa via Dopa carboxylase

Answer 2

Carbidopa

Question 3

DOC for Parkinsons

Answer 3

Levodopa-Carbidopa

Question 4

Side effect seen on Levo-Carbi

Answer 4

On off phenomenon

Question 5

Partial agonist at D2 receptors

Answer 5

Bromocriptine
Pramipexole

Question 6

Agonist at D2 receptor

Answer 6

Apomorphine

Question 7

Used in HYPERPROLACTINEMIA

Answer 7

Bromocriptine

Question 8

S/E of Ergot alkaloids (Bromocriptine)

Answer 8

Erythromelalgia
Pulmonary infiltrates

Question 9

Used in treatment of Compulsive gambling, hypersexuality, and overeating

Answer 9

Non-ergot (Pramipexole, Ropinirole)

Question 10

Used as rescue treatment for off-periods of Parkinson’s disease

Answer 10

Apomorphine

Question 11

Selective inhibitors of monoamine oxidase type B

Answer 11

MAO-B inhibitors (Selegiline, Rasagiline)

Question 12

S/E seen in MAO-B inhibitors

Answer 12

Serotonin syndrome

Question 13

Block L-dopa metabolism by inhibiting catechol-O-methyltransferase in periphery and CNS

Answer 13

COMT inhibitors

Tolcapone (CNS and peripheral)
Entacapone (peripheral only)

Question 14

S/E seen in COMT inhibitors

Answer 14

Orange urine

Question 15

Antiviral that may be used in Parkinson’s

Answer 15

Amantadine

Question 16

S/E of Amantadine

Answer 16

Livedo reticularis

Question 17

Anticholinergic for Parkinsonism

Answer 17

Benztropine
Biperidine
Trihexyphenidyl
Procyclidine