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Pharma > ANTIVIRAL CHEMOTHERAPY AND PROPHYLAXIS > Flashcards

ANTIVIRAL CHEMOTHERAPY AND PROPHYLAXIS Flashcards

1
Q

Activated by viral thymidine kinase (TK) to forms that inhibit viral DNA polymerase

A

Acyclovir

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2
Q

Used in HSV-1, HSV-2, and VZV

A

Acyclovir

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3
Q

Inhibits fusion between the HSV envelope and plasma membranes

A

Docosanol

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4
Q

An investigational drug which acts as an inhibitor of viral DNA polymerase for shingles and EBV

A

Valomaciclovir

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5
Q

Prodrug that is converted to Acyclovir

A

Valacyclovir

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6
Q

Inhibits viral DNA polymerase, causing chain termination

A

Ganciclovir
Cidofovir

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7
Q

CMV

A

Ganciclovir
Cidofovir

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8
Q

Foscarnet inhibits these enzymes (3):

A

RNA polymerase
DNA polymerase
Reverse transcriptase

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9
Q

HSV infection in patients with AIDS

A

Foscarnet

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10
Q

Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)

A

Never EvEr Deliver nucleoside

Nevirapine
Efavirenz
Etravirine
Delavirdine

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11
Q

Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes

A

Nucleoside Reverse Transcriptase inhibitors (NRTIs)

Zidovudine
Abacavir
Didanosine
Emtricitabine
Lamivudine
Stavudine
Tenofovir
Zlcitabine

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12
Q

Used for prevention of maternal-fetal HIV transmission

A

Nucleoside Reverse Transcriptase Inhibitor

NRTIs safe for pregnancy

LATE

L - Lamivudine
A - Abacavir
T - Tenofovir
E - Emtricitabine

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13
Q

Nucleoside Reverse Transcriptase Inhibitor (NRTIs) side effects

A

Lactic acidosis with hepatic steatosis

Zidovudine: BM supression
Abacavir: Hypersensitivity
Didanosine: Pancreatitis
Stavudine, Zalcitabine: Peripheral neuropathy

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14
Q

Inhibit HIV reverse transcriptase. NO PHOSPHORYLATION REQUIRED

A

Non-nucleoside RT inhibitors

Never EvER Deliver nucleoside

N - Nevirapine
E - Efavirenz
E - Etravirine
R - Rilpivirine
D - Delavirdine

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15
Q

Side effects of NNRTIs

A

No BM suppression because not incorporated in DNA

Delavirdine: Rash, elevated AST/ALT
Efavirenz: Teratogenicity
Etravirine: Increased cholesterol, TAG

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16
Q

Inhibits viral protein processing

A

Protease inhibitor (Indinavir)

17
Q

Side effects seen in Protease inhibitors (Indinavir)

A

Hyperlipidemia
Fat redistribution
Hyperglycemia
Insulin resistance

Indinavir: Hyperbilirubinemia, nephrolithiasis
Amprenavir: rash
Atazanavir: peripheral neuropathy
Atazanavir, Fosamprenavir, Lopinavir, Lekfinavir, Saquinavir: GI distress and diarrhea

18
Q

Binds to gp41 subunit of viral envelope glycoprotein

A

Fusion inhibitor (Enfuvirtide)

Enfu - ENvelope FUsion

19
Q

Blocks viral attachment via transmembrane chemoKine receptor CCR5

A

MaraviroC

20
Q

Integrase inhibitor (an enzyme essential for replication of HIV) leading to inhibition of strand transfer

A

Raltegravir
Dolutegravir

GRAVIR

21
Q

Uncoating inhibitor that inhibits early step of replication and prevents uncoating by binding to M2 proton channels

A

Uncoating inhibitors (Amantadine, Rimantadine)

22
Q

Anti-viral for Influenza A only

A

Amantadine

23
Q

Side effect of Amantadine

A

Livedo reticularis

24
Q

Antiviral against Influenza A that is also used in treating Parkinsonism

A

Amantadine

A for Influenza A
Amantada - for matanda with Parkinsonism

25
Q

Neuraminidase inhibitor that decreases release of progeny virus

A

MIVIRs

Oseltamivir
Zanamivir
Peramivir

26
Q

Antiviral against both Influenza A & B

A

Neuraminidase inhibitors

MIVIRs

Oseltamivir
Zanamivir
Peramivir

27
Q

S/e seen in Oseltamivir use

A

GI effects

O for oral

28
Q

S/E seen in Zanamivir

A

Bronchospasm in asthmatics

29
Q

Drug of choice for Influenza including H1N1

A

Oseltamivir

30
Q

Degrades viral RNA via activation of host cell RNAse (ribonuclease). Used in HBV, HCV, Kaposi sarcoma, genital warts.

A

Interferon-alpha

31
Q

Inhibits GTP formation. Used in HBV and RSV

A

Ribavirin

32
Q

Inhibits HBV DNA polymerase. Used in HBV and HIV infection

A

Lamivudine

33
Q

Miscellaneous antiviral: an immune response modifier effective for external genital and perianal warts

A

Imiquimod

34
Q

Miscellaneous antiviral: licensed for the treatment of cell-mediated immune deficiencies associated with viral infections; used for genital warts, herpes virus infection, SSPE.

A

Inosine Acedoben Dimepranol

Pharma (31 decks)

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