RNA VIRUS - RHABDOVIRIDAE - Rabies virus Flashcards

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1
Q

BULLET SHAPED

enveloped, helical, non-segmented, (-) ssRNA

A

Rabies virus

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2
Q

Animal reservoirs of rabies

A
DOGS
CATS
SKUNKS
RACCOONS
BATS
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3
Q

Pathogenesis of Rabies

A

when human is bitten the virus replicates locally at the wound site for a few days then migrates (15-100 mm/day) up to nerve axons to the CNS – RETROGRADE TRANSPORT

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4
Q

Incubation period of rabies

A

2 weeks to 6 years (depending on the site of the bite)

*the only time when vaccination is effective

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5
Q

Symptoms of rabies

A

fever, headache, sore throat, fatigue, nausea

pain/itchiness/paresthesia - 1st RABIES SYMPTOMS

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6
Q

Encephalitic/Furious Rabies

A

Phobic spasms: hydrophobia, aerophobia
Fluctuating consciousness
Autonomic instability

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7
Q

Paralytic/Dumb Rabies

A

Percussion myoedema

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8
Q

Follows the acute neurologic period regardless of the presentation

A

Coma

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9
Q

Cytoplasmic round to oval eosinophilic inclusions

A

NEGRI BODIES

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10
Q

Common site of Negri Bodies

A

pyramidal neurons of the HIPPOCAMPUS

purkinje cells of the CEREBELLUM

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11
Q

GOLD STANDARD in the detection of rabies specific antigen

A

Immunofluorescent Antibody Test (IFAT)

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12
Q

CATEGORY I

A

touching or feeding animals, licks on intact skin

NO TREATMENT

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13
Q

CATEGORY II

A

minor scratches or abrasions w/o bleeding or licks on broken skin and nibbling of uncovered skin

VACCINE

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14
Q

CATEGORY III

A

single or multiple transdermal bites or scratches

contamination of mucous membranes w/ saliva from licks

exposure to bat bites/scratches

all category II exposures on head and neck

VACCINE + Immunoglobulin

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