DNA VIRUS - VARICELLA-ZOSTER VIRUS (VZV/HHV-3)

Question 1

Transmission of VZV/HHV 3

Answer 1

AIRBORNE-droplet

Direct contact w/ lesions

Question 2

VZV/HHV 3 site of latency

Answer 2

DORSAL ROOT OR TRIGEMINAL GANGLIA

Question 3

Incubation period VZV

Answer 3

14-21 days

Question 4

Vesicular rash (DEWDROP ON A ROSE PETAL APPEARANCE that begins on TRUNK spreads to FACE and EXTREMITIES (CENTRIFUGAL) with lesions of DIFFERENT STAGE

Answer 4

Varicella/Chicken Pox

Question 5

Complications of VZV/HHV-3

Answer 5

Pneumonia
Encephalitis
Reye's syndrome
Cerebellar ataxia
Secondary bacterial infection

Question 6

UNILATERAL painful vesicular eruption w/ DERMATOMAL DISTRIBUTION (THORACIC and LUMBAR)

Answer 6

Herpes Zoster/ Shingles

Question 7

MC complication of Herpes Zoster/Shingles

Answer 7

POSTHERPETIC NEURALGIA

Question 8

Reactivation of latent VZV residing within GENICULATE GANGLION

Answer 8

Ramsay Hunt Syndrome/ Herpes Zoster Oticus

Question 9

Ipsilateral Facial Paralysis
Ear Pain
Vesicles (Face, Ear)

Answer 9

Ramsay Hunt Syndrome/Herpes Zoster Oticus

Question 10

Congenital Varicella - 6-12 weeks

Answer 10

Maximal interruption w/ LIMB DEVT

• short and malformed limbs covered w/ CICATRIX
• skin lesion w/ ZIGZAG SCARRING associated w/ atrophy of the affected limb

Question 11

Congenital Varicella - 16-20 weeks

Answer 11

EYE and BRAIN DEVELOPMENT

Question 12

Treatment for Moderate to Severe Varicella

Answer 12

ACYCLOVIR

*most effective if within 24 hrs of the onset of rash

Question 13

Treatment for Ramsay-Hunt Syndrome

Answer 13

Valacyclovir

Prednisone

Question 14

Can be given w/n 5 days of exposure of modify course

Answer 14

ACTIVE VACCINE

Question 15

Given w/n 96 hrs AFTER EXPOSURE for PREGNANT, NEWBORNS exposed to MATERNAL VARICELLA and IMMUNOCOMPROMISED

Answer 15

Anti-VZV Ig