RNA VIRUS - FLAVIRIDAE - Hepatitis C Flashcards
1
Q
Enveloped, icosahedral, non-segmented, (+) ssRNA
A
Hepatitic C
2
Q
Reservoir for HCV
A
Humans
3
Q
Replication of HCV in the liver is enhanced by LIVER SPECIFIC MICRO RNA
A
miR -122
4
Q
Causes death of hepatocytes
A
immune attack by cytotoxic T cells
5
Q
Greatly enhances the rate of hepatocellular carcinoma
A
Alcoholism
6
Q
Incubation period of HCV
A
8 weeks
7
Q
HCV infection leads to AUTOIMMUNE REACTIONS and EXTRAHEPATIC MANIFESTATIONS
A
thyroiditis autoimmune hemolytic anemia ITP MPGN porphyria cutanea tarda DM leukocytoclastic vasculitis increase risk of B cell NHL lichen planus
8
Q
The main cause of essential mixed cryoglobulinemia
A
HCV
9
Q
Chronic Infection
A
elevated transaminase level
(+) RIBA
detectable viral RNA for at least 6 mos
10
Q
Treatment for Acute Hepatitis C
A
Peginterferon alfa
11
Q
Treatment for Chronic Hepatitis C
A
Peginterferon alfa-2a
Ribavirin
12
Q
The MC indication for liver transplantation
A
Cirrhosis d r. chronic HCV infectio
