RNA VIRUS - PARAMYXOVIRIDAE - Measles virus Flashcards

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1
Q

Enveloped, helical, non-segmented ss-negative RNA

A

measles virus

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2
Q

Pathogenesis of measles

A

measles virus infects the cells lining the URTI – enters BLOOD – infects REC – spreads via the blood to the skin – CYTOTOXIC T CELLS attack the measles virus-infected vascular endothelial cells in the skin – RASH – virus can no longer be recovered – patient can no longer spread virus to other

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3
Q

Incubation period of measles

A

10-14 days

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4
Q

Period of communicability of measles

A

4 days BEFORE and 4 days AFTER the onset of the rash

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5
Q

Pathognomonic enanthem pf measles

A

Koplik’s spots

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6
Q

Bright red lesions w/ a white central dot on the buccal mucosa

A

Koplik’s spots

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7
Q

Timing of appearance of rash in measles

A

height of the fever

cephalocaudal appearance of maculopapular rash - FACE – TRUNK – EXTREMITIES – PALMS/SOLES

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8
Q

Rash fades in the same sequence in which it appears

A

BRANNY DESQUAMATION

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9
Q

Complications of Measles

A

Otitis Media

Giant Cell Pneumonia, Secondary Bacterial Pneumonia

Higher rate of activation of PTB

Subacute Sclerosing Panencephalitis (SSPE/Dawson Disease)

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10
Q

Neurodegenerative disease caused by persistent infection of the brain by an altered form of the measles virus

Manifests 5-7 years after initial infection

A

Subacute Sclerosing Panencephalitis (SSPE/Dawson Disease)

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11
Q

Final common pathway to a fatal outcome in measles

A

Bronchiolitis obliterans

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12
Q

Inclusion bodies in Measles

A

WARTHIN FINKELDAY BODIES - multinucleated giant cells

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13
Q

multinucleated giant cells which form as a result of the FUSION PROTEIN in the SPIKES

A

WARTHIN FINKELDAY BODIES

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14
Q

Can reduce morbidity and mortality from measles particularly in malnourished children

A

VITAMIN A

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15
Q

Cardinal manifestations of Measles

A

Cough
Coryza
Conjunctivitis
C(K)oplic spots

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