RNA VIRUS - FLAVIRIDAE - Dengue virus Flashcards

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1
Q

Enveloped, icosahedral, non-segmented, (+) ssRNA

A

Dengue virus

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2
Q

4 serotypes of Dengue

A

Den - 1,2,3,4

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3
Q

Transmission of dengue

A

Bite of female Aedes aegypti, Aedes albopictus

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4
Q

Influenza like syndrome characterized by BIPHASIC FEVER, MYALGIA, ARTHRALGIA

A

Dengue Fever ( Breakbone fever)

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5
Q

Severe often fatal febrile disease

capillary permeability
abnormalities of homeostasis
protein losing shock syndrome

A

Dengue Hemorrhagic Fever

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6
Q

Detect gene product (NS-1 glycoprotein) from day 1 until day 6 from the onset of fever

A

NS1 Antigen

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7
Q

Detect dengue viral genes (RNA) in acute phase serum samples which coincide with the onset of viremia

A

RT-PCR

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8
Q

Marker of RECENT infection

A

Dengue IgM

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9
Q

Marker of past infection

A

Dengue IgG

4FOLD increase confirms the diagnosis

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10
Q

Complete Blood Count and Platelet Count Findings

A

Thrombocytopenia w/ Leukopenia

hematocrit level increase > 20%

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11
Q

Dengue Vaccine (Dengvaxia)

A

LIVE RECOMBINANT TETRAVALENT dengue vaccine

given as 3 dose series

0/6/12

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12
Q

The MC insect borne viral disease in the world

A

Dengue

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