RNA VIRUS - RETROVIRIDAE - HIV

Question 1

Converts a SINGLE STRANDED RNA VIRAL GENOME into a DOUBLE STRANDED VIRAL DNA (ssRNA –> dsDNA)

Answer 1

Reverse transcriptase

Question 2

Located in the CORE

group specific antigen

Answer 2

p24

Question 3

Interacts w/ the CD4 receptor

MUTATES RAPIDLY – many antigenic variants

Answer 3

gp120

Question 4

Most immunologic region of gp120

Answer 4

V3 loop

Question 5

Mediates the FUSION of the viral envelope with the cell membrane at the time if infection

Answer 5

gp41

Question 6

CD4 < 500

Answer 6

M. TUBERCULOSIS- disseminated tuberculosis

HSV - HSV esophagitis

C. ALBICANS - esophageal candidiasis

HHV - 8 - Kaposi sarcom

Question 7

CD4 < 200

Answer 7

P.JIROVECI - PCP pneumonia
T. GONDII - cerebral toxoplasmosis
C. NEOFORMANS - meningoencephalitis
C. IMMITIS - coccidiodomycosis
C. PARVUM - chronic diarrhea

Question 8

CD4 <50

Answer 8

M.AVIUM - invasive pulmonary disease
H. CAPSULATUM - histoplasmosis
CMV - CMV retinitis

Question 9

HIV acquired through sexual intercourse, blood or perinatally

Answer 9

PHASE 0

Infection

Question 10

RAPID VIRAL REPLICATION but HIV test is NEGATIVE

Answer 10

PHASE 1

Window Period

Question 11

PEAK of VIRAL LOAD

(+) HIV test

mild flu like illness lasting 1-2 weeks

Answer 11

PHASE 2

Seroconversion

Question 12

asymptomatic
CD4 goes DOWN
lasts 1-15 years

Answer 12

PHASE 3

LATENT PERIOD

Question 13

CD4 500 - 200
lasts 5 years
mild mucocutaneous, dermatologic and hematologic illnesses

Answer 13

PHASE 4

Early Symptomatic

Question 14

CD < 200
lasts 2 years
AIDS-defining illness develop

Answer 14

PHASE 5

AIDS

Question 15

The 2 most characteristic manifestations of AIDS

Answer 15

Pneumocystis pneumonia

Kaposi’s sarcoma

Question 16

SNoW DRoP

Answer 16

Southern - DNA
Northern - RNA
Western - Proteun