Respiratory Pathology

Question 1

What causes bronchiectasis? How?

Answer 1

• Post-inflammatory (infection) or obstructive (neoplasm, FB, asthma)
• Recurrent inflammation and fibrosis leads to traction on surrounding walls and dilation

Question 2

What is progressive TB?

Answer 2

• TB spread that can follow directly from primary infection if immunosuppressed (miliary, cavitary fibrocaseous, bronchopneumonia)
• Contrast with secondary TB (reactivation of contained primary TB)

Question 3

How often does ARDS resolve as honeycomb lung?

Answer 3

50% of the time

Question 4

Which lung tumours are most common in non-smokers. How is their origin determined if thought to be secondary?

Answer 4

• Adenocarcinoma
• CK staining (7 above diaphragm, 20 below)

Question 5

Which lung cancers are most associated with smoking? Can you distinguish between primary and secondary?

Answer 5

• SCC
• No

Question 6

Which gene mutations are most important in the targeted treatment of adenocarcinoma?

Answer 6

• EGFR, ALK