Prostate Cancer

Question 1

Where do most prostate cancers arise?

Answer 1

• The peripheral zone (subcapsular posterior prostate)

Question 2

What are the likely findings on history and examination in a person with prostate cancer?

Answer 2

• >50
• FHx
• High fat diet
• Nocturia
• Frequency
• Hesitancy
• Dysuria
• Hard, nodular prostate on DRE

Question 3

What are the general management prinicples for a person with prostate cancer?

Answer 3

• Short expected survival
  
  • Active surveillance
• Confined to prostate
  
  • Radio/brachytherapy, androgen deprivation therapy (flutamide)
    
    • Prostatectomy (if high risk)
• Metastatic
  
  • Chemo/radiotherapy, androgen deprivation therapy