Research; Part 1 Flashcards
Learning outcomes:
- What is research?
- What is “isolated research”?
- How is medical research conducted and funded?
- Research assumptions and shortcomings?
- Natural assumptions and shortcomings?
- Natural medicine research.
- Natural medicine concepts formed from research – observation and practice.
Definitions: Research
The systematic study of a subject in order to establish facts and reach new conclusions.
Definitions: Research Synonyms
Investigation, experimentation, testing, exploration, analysis, fact-finding, examination.
Definitions: Isolated research
Looks only at an isolated part of the whole picture and thereby draws false conclusions from it.
Definitions: Science
The systematic study of the structure and behaviour of the physical and natural world through observation and experiment.
Medical approach
The medical approach to disease:
* The symptom is the disease (high blood pressure, eczema, arthritis). The symptom is the disease and cause at the same time.
* Sometimes there is little attempt to establish the real cause – Poor diet, stress, drug adverse effects, environment, poor function of an organ, etc.
* If no measurable observed symptoms are found, the patient Is pronounced ‘healthy’, even though they feel sick.
* When symptoms have become chronic over decades, and measurable tissue changes have taken place, a patient can be declared as “sick”, often too late to be successfully treated.
Medical approach examples
Instead of establishing connections such as:
* Diabetes = poor diet
* stomach ulcer = chronic anger
* dizziness = drug adverse effect,
Medical researchers take the symptom (the “output”) as the disease:
For example:
* Type 2 diabetes; Therapy = Metformin (increases insulin sensitivity)
* Stomach ulcer; Therapy = proton pump inhibitors (inhibit stomach acid production).
* High cholesterol; Therapy = statins (lower cholesterol)
Not addressing the cause means the disease continues. The patient gets worse over time and additionally must deal with adverse effects resulting from the ‘orthodox’ treatment given.
Medical approach; Suppression
Symptoms in medicine are considered as causes in their own right and treated as such.
* This kind of treatment is called suppression. It makes a symptom disappear without treating the true cause.
Examples:
* Fever: anti-inflammatories; weaken that immubne system
* Pain: painkillers including opiates; cause intolerance, i.e. patient requires more and more drugs for the same effect.
* Allergy: antihistamines to suppress the body’s response.
Suppression always drives the disease deeper into the body.
Isolated research
An example of a isolated research:
* Alzheimer’s disease: medicine believes the Alzheimer’s is caused by the accumulation of plaques in the brain made of protein called amyloid – beta (AB or Abeta). Outsiders is considered a single disease, but no explanation is given to the presence of amyloid– beta protein.
* Amyloid is a potent pathogen fighter and part of the protective response of the brain to invading pathogens and sub optimal levels of nutrients.
* Getting rid of amyloid beta is, therefore, not a successful treatment for Alzheimer’s and can be damaging. Natural medicine instead looks at why the beta amyloid has formed.
Medical research
Medical research:
* Not searching for the true cause of disease (lifestyle, diet, environment, organ dysfunction, stress, etc.)
* Isolates specific aspects of the problem without reference to the whole picture.
* Is almost exclusively funded to fulfil purpose – sets out to prove what industry wants to sell.
* Is subject to distortion due to the focus of removing the symptom(s), rather finding and treating the cause.
* Is, therefore, very naïve – remove the symptom (e.g. pain) and you have cured the disease.
* In general looks at isolated situations or symptoms (in vitro research, research on tissues, controlled clinical trials).
Medical research on animals
Research on Animals:
Laboratory animals are under stress; results are, therefore, false:
* Stress hormones increase; metabolism changes; functions of cells and organs are thereby distorted.
* Animal studies are inhumane in brutal. Animals have feelings too
* Animal physiology is different from human.
Competing paradigms
- Louis Pasteur (French biologist): developed ‘Germ theory’: disease comes from outside the body, bacteria, viruses, fungi responsible for diseases.
- Antoine Bechamp (French scientist, rival of Pasteur) developed ‘Terrain theory’. Disease occurs from within the body (negative changes in terrain responsible for disease). Bacteria/viruses are the ‘after effects’ not the cause of disease. Diseases are the result of an acidic, low oxygenated terrain where the diseased tissue supports the growth of microorganisms, which can develop into different forms (pleomorphism = “many forms”).
Medical research: randomised clinical trial (RCT)
Medical research: the gold standard clinical trial (RCT):
RCT = Randomised (double blinded) placebo-Controlled Trial
Randomised = intervention is given at random
Placebo = inert substance with supposedly no effort.
* Research that has limitations. Conducted on humans, involving a specific intervention (often the drug), to be tested against a placebo.
* Depends upon ensuring that each respondent has an identical pathology and no other complicating factors.
* Is often conducted in a ‘clinical’ environment i.e. a space where nothing ‘normal’ happens.
* Is subject to strict ‘Scientific’ rules, including that neither the patient’s nor the physicians administering the trial know who is getting the real drug, and who is getting the placebo (double blinding).
Other weaknesses of the RCT:
* Real people don’t come as ‘standard’ – they have different lifestyles, diets, constitutions, and medical preferences.
* RCT’s are not concerned with causes, just whether the drug works to suppress the symptom or not.
* Clinical situations do not reflect real life, abnormal environments will create abnormal responses.
* Drugs tested are single molecules and no attempt is made to test alongside co-medications which the patient maybe taking.
* Data can easily be ‘cherry picked’ – results that support the hypothesis Doctor; all of the results discarded.
* ‘Placebo effect’ is well known to work…
Research in the food industry: Coffee
Coffee: latest research promotes coffee is healthy, but…
* It leads to physical dependency
* It can aggravate other addictions such as smoking, sugar, sweets and empty carbs.
* It impairs sleep and can over-stimulate the adrenals resulting in exhaustion
* It increases the stress hormone cortisol, which causes weight gain and increases blood sugar and Type II diabetes. Cortisol also suppresses the immune system leading to recurrent infections.
* It suppresses reproductive and thyroid functions
Coffee research: isolated research, looking at isolated chemicals. $42 billion sales/year – may double by promoting ‘health benefits’.
Research in the food industry: Alcohol
Alcohol: “French get fewer heart-attack because they drink wine”: but…
* The overall effect of alcohol even in small amounts is detrimental (changes in the brain and liver, reduced reaction time, negative effects of alcohol additives, etc.).
* The researchers conducted on an isolated constituent of wine which may reduce heart attacks, but the negative effect of alcohol content is not considered: fails to see the whole picture.
* Does not consider other variables in French culture (e.g. good food, taking time, less stress, garlic consumption).
* Result: drink daily 1-4 glasses of red wine. Become a regular customer and, ultimately, a possible addict.
Research funding
It is vital to know who funds the research, as this generally dictates the results of the ‘research’ e.g.:
* Drug/food research funded by the pharma and food industry is an integral part of licensing and selling products.
* Food research funded by the food industry is in an integral part of getting food products on the shelves and promoting them to the public
* ‘Natural medicine” research is often funded by universities and conducted by ‘scientists’ who do not know anything about natural medicine; the purpose is often to debase and disprove it
* Medical research is uniquely designed for the testing of isolated pharmaceutical drugs
The Pharma and Food Industry
The pharmaceutical and food industries finance most of the clinical trials into their products.
* A finance/influence universities and the continuing education of medical doctors and dieticians, build new hospitals and wards.
* Clinical trials are often conducted on small groups of unrepresentative subjects
* Negative data is routinely withheld, and researchers fired if their findings of negative
* Supposedly independent academic papers may be commissioned and even ghost-written by pharmaceutical companies or their contractors, without disclosure
Research Assumptions; Biomedical research
Biomedical research:
. Aims to demonstrate the effectiveness of a single treatment intervention e.g. a drug
. Is funded by vested interests for profit: major expense of the pharmaceutical companies
. Cuts out complexity and variability as far as possible: tests simplistic hypotheses
. Only useful for what can be precisely measured
. Assumes that patients (people) are all the same and will respond similarly to drugs
Research Assumptions; Natural medicine research
Natural medicine research:
. Aims to demonstrate the effectiveness of a treatment strategy in any particular case
. Natural products and treatments cannot be patented, therefore, few if any profits to be made.
. Embraces complexity and variability is part of life and therefore, patient experience
. Precise measurements not important in the context of overall outcome
. Assumes that patients are different and works to develop greater individualisation in treatments.
Research Assumptions; ‘Objectivist’ science
Problems with ‘Objectivist’ Science:
* Maintains that everything exists independently (objectively) of what we think or feel. Ignores individual truth.
* We must be able to measure everything.
* Knowledge of the past is unverifiable (hasn’t been measured), and Therefore must be tested again
* The only valid kind of research is quantitative and measurable
* Individual variations are merely ‘confounding factors’ to be ruled out of investigation
Natural medicine research; traditional medicine
Traditional medicine and research:
* Traditional healers of the past developed highly sophisticated treatment methods based on observations in practice.
* Once something his known, it can be experienced by others and doesn’t need to be tested again and again. Concepts and methods that have been demonstrated to work in practice, can be reapplied with success.
* Knowledge comes from better sources than the scientist’s laboratories.
* Traditional healers gain their results in many years of practice, as opposed to theoretical learning.
Natural medicine research; patients choice
Patients know what works for them:
* You know what is true for you.
* No one has the right to tell you that it doesn’t work based on some experiment that has nothing to do with you.
* The way patients feel about their treatment and their practitioner is part of the process and can facilitate healing.
* The more a patient engages with their personal situation, e.g. changing their lifestyle, healing themselves, the more success we see in practice.