Orthomolecular - Methyl Sulfonymethane (MSM)

Question 1

Methyl Sulfonymethane (MSM)

Answer 1

• Methyl sulfonylmethane (MSM) is a source of sulphur used by plants to create the amino acids, cysteine and methionine. These amino acids are a dietary source of sulphur.

Question 2

Food Sources

Answer 2

• Plant food sources: Green leafy vegetables, alfalfa sprouts, algae, fruits, vegetables, and grains.
• Animal sources: Milk (cows).

Question 3

Osteoarthritis

Answer 3

Therapeutic uses:
* Alone or in combination with glucosamine / chondroitin, it can reduce pain and swelling and improve joint function.
* General anti-inflammatory properties by inhibiting the secretion of cytokines (IL-6 and TNF-α) and COX-2.
* Sulphur is a component of cartilage and so exerts a protective effect on cartilage.
* Dosage: 500 mg three times a day.

Question 4

Cardiovascular health

Answer 4

Therapeutic uses:
* MSM reduces homocysteine levels (by donating methyl groups) and reduces lipid peroxidation.
* This protects the vascular endothelium from damage.
* Dosage: 3 g per day (benefits observed at 28 days).

Question 5

Tissue repair

Answer 5

Therapeutic uses:
* Decreases oxidative stress and inflammation which helps to repair GI mucosal injury and ↓ chronic GI inflammation.
* Supports tissue healing after an injury (including the skin).
* Can be applied topically to affected skin.
* Dosage: 2 g two to three times daily.

Question 6

Immune
modulator

Answer 6

Therapeutic uses:
* The immune-regulating and antioxidant properties of MSM make it useful for seasonal allergies and ↓ inflammation.
* Studies show that MSM inhibits NF-κB activity, downregulating inflammatory cytokines.
* Dosage: 2.6 g per day for seasonal allergies.

Question 7

Supplementation:

Answer 7

• Generally recognised as very safe. Well tolerated up to 4 g per day in most patients.
• Mild adverse effects: GIT symptoms such as nausea, diarrhoea and bloating. Other symptoms include headache, difficulty concentrating and insomnia.
• Interactions: None