Orthomolecular - Phosphatidylcholine

Question 1

Phosphatidylcholine (PC)

Answer 1

Phosphatidylcholine (PC) is a major structural component of cell membranes, maintaining their integrity and fluidity.
* It is synthesised from dietary choline or through the methylation of another phospholipid —phosphatidylethanolamine.
* While the body can synthesise a small amount of choline, dietary intake is essential to meet body demands —about 95% of body tissue stores of choline are found in PC.

Question 2

PC food sources:

Answer 2

• Plant sources: Nuts, peanuts, wheatgerm, Brussels sprouts, broccoli, spinach, peas.
• Animal sources: Eggs, fish, beef, chicken, pork, liver.

Question 3

Liver health

Answer 3

Therapeutic uses:
* Prevents fat accumulation in the liver and is hepato-protective reducing chemical and oxidative damage.
* Consider for non-alcoholic fatty liver disease, alcoholic hepatic steatosis, drug-induced liver damage and hepatitis.
* Dosage: Minimum 800 mg daily.
hepato-protective =protects liver cells from damage

Question 4

Neurological health

Answer 4

Therapeutic uses:
* PC has a neuro-protective role as an essential component of neuronal membranes and supplies choline for the synthesis of the neurotransmitter acetylcholine.
* Acetylcholine is a neurotransmitter involved in memory and is protective against cognitive decline and dementia.
* Dosage: 1–9 grams / day in divided doses.

Question 5

Ulcerative colitis

Answer 5

Therapeutic uses:
* PC plays an important role in establishing a protective mucosal barrier and forms a vital part of intestinal mucus.
* Incorporates into enterocyte membranes to influence signalling cascades and reduce inflammation.
* Dosage: 1–6 g daily in divided doses.

Question 6

Supplementation

Answer 6

• Mild adverse effects: Gastrointestinal symptoms.
• Interactions: Possible additive effect when combined with cholinergic drugs which increase acetylcholine.
• May decrease effectiveness of anticholinergic medications.