Rate-determining enzymes of metabolic processes Flashcards
Positive and negative regulators of PFK-1
positive –> AMP, f-2-6-BP
negative –> ATP, citrate
Positive and negative regulators of F-1,6-BP
positive –> citrate
negative –> AMP, F-2-6-BP
Positive and negative regulators of isocitrate dehydrogenase
positive –> ADP,
negative –> ATP, NADH
Positive and negative regulators of glycogen synthase
positive –> G-6-P, insulin, cortisol
negative –> epinephrine, glucagon
Positive and negative regulators of glycogen phosphorylase
positive –> epinephrine, glucagon, AMP
negative –> G-6-P, insulin, ATP
Positive and negative regulators of G6PD
positive –> NADP+
negative –> NADPH
Positive and negative regulators of carbamoyl phosphate synthetase II
positive –> ATP
negative –> UTP
Positive and negative regulators of glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase
positive –> AMP, inosine monophosphate (IMP), GMP
negative –>
Positive regulators of carbamoyl phosphate synthetase I
positive –> N-acetylglutamate
Positive and negative regulators of acetyl-CoA carboxylase (ACC)
positive –> insulin, citrate
negative –> glucagon, palmitoyl-CoA
Negative regulators of carnitine acyltransferase I
negative –> malonyl-CoA
Positive and negative regulators of HMG-CoA reductase
positive –> insulin, thyroxine
negative –> glucagon, cholesterol
rate limiting enzyme of fatty acid synthesis
acetyl-CoA carboxylase (ACC)
rate limiting enzyme of ketogenesis
HMG-CoA synthase
rate limiting enzyme of cholesterol synthesis
HMG-CoA reductase
