Neuro XI Flashcards

1
Q

hemangioblastoma path description

A

closely arranged, thin-walled capillaries with minimal intervening parenchyma.

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2
Q

classic location of schwannoma

A

cerebellopontine angle

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3
Q

schwannoma management

A

Resection or stereotactic radiosurgery

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4
Q

Schwanzoma tumor marker

A

S-100

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5
Q

most common site of oligodendroglioma

A

frontal lobes

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6
Q

other findings in oligodendroglioma

A

1) “chicken-wire” capillary pattern

2) often calcified

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7
Q

pilocytic astrocytoma prognosis

A

benign; good prognosis

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8
Q

pilocytic astrocytoma location

A

Posterior fossa (cerebellum). May be supratentorial

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9
Q

characteristic path findings in pilocytic astrocytoma?

A

Rosenthal fibers

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10
Q

Rosenthal fibers description

A

Eosinophilic, corkscrew fibers.

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11
Q

gross finding of pilocytic astrocytoma

A

cystic + solid

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12
Q

medulloblastoma personality

A

1) highly malignant

2) form of primitive neuroectodermal tumor

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13
Q

medulloblastoma pathology

A

1) Homer-Wright rosettes

2) small blue cells

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14
Q

Most common site of ependymal cell tumors?

A

4th ventricle

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15
Q

ependymoma pathology

A

1) Characteristic perivascular rosettes

2) Rod-shaped blepharoplasts

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16
Q

blepharoplasts?

A

(basal ciliary bodies) found near nucleus

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17
Q

craniopharyngioma histology

A

1) calcification common

2) cholesterol crystals found in “motor oil” like fluid within tumor

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18
Q

pinealoma presentation in males

A

precocious puberty due to beta-hCG preoduction

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19
Q

pinealoma histology

A

similar to seminoma (late cells in lobules with watery cytoplasm and “fried egg” appearance)

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20
Q

Downward (transtentorial) central herniation

A

Caudal displacement of brain stem leads to rupture of paramedic basilar artery branches –> duret hemorrhages. Usually fatal.

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21
Q

cingulate herniation complication

A

con compress ACA

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22
Q

cingulate/subfaciline herniation

A

Innermost part of the frontal lobe is scraped under part of the fall cerebra.

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23
Q

duret hemorrhage

A

Small lineal areas of bleeding in the midbrain and upper pons of the brainstem caused by a traumatic downward displacement of the brainstem.

24
Q

central herniation AKA

A

transtentorial herniation

25
central herniation pathophys
Caudal displacement of brain stem --> rupture of paramedic basilar artery branches --> Duret hemorrhages. Usually fatal.
26
Uncal herniation pathophys
1) Compresses *ipsilateral CN III 2) compresses ipsilateral PCA (leading to contralateral homonymous hemianopia with macular sparing) 3) compresses contralateral crus cerebri at the Kernohan notch (leading to ipsilateral paresis; "false localization sign")
27
what herniates with uncal herniations?
medial temporal lobe
28
tonsillar herniation pathophys
cerebellar tonsills herniate through foramen magnum leading to coma and death due to brain stem compression.
29
Brimonidine MOA
a2 agonist
30
epinephrine MOA for glaucoma?
Decreases aqueous humor synthesis via vasoconstriction.
31
brimonidine MOA for glaucoma?
Decreases aqueous humor synthesis
32
epinephrine contraindication
closed-angle glaucoma (mydriasis)
33
brominidine AE's
1) blurry vision 2) ocular hyperemia 3) foreign body sensation 4) ocular allergic reactions 5) ocular pruritis
34
b-blockers used in glaucoma?
1) timolol 2) *betaxolol 3) carteolol
35
b-blockers AE's in glaucoma
no pupillary or vision changes
36
acetazolamide MOA in glaucoma
decreases aqueous humor synthesis via inhibition of carbonic anhydrase
37
acetazolamide AE's in glaucoma
no pupillary or vision changes
38
drug for use in glaucoma emergency's? why?
pilocarpine (very effective at opening meshwork into canal of schlemm)
39
cholinomimetic MOA for glaucoma
Increase outflow of aqueous humor via contraction of ciliary muscle and opening of trabecular meshwork.
40
cholinomimetic AE's
miosis (contraction of pupillary sphincter muscles) + cyclospasm
41
cyclospasm
contraction of ciliary muscle
42
latanprost
PGF2alpha
43
prostaglandins for use in glaucoma?
1) bimatoprost | 2) latanoprost
44
prostaglandin mechanism for glaucoma?
Increase outflow of aqueous humor
45
bimatoprost/latanoprost AE's
1) darken color of iris (browning) | 2) eyelash growth
46
diphenoxylate
opioid analgesic
47
pentazocine
opioid analgesic
48
mu receptor is for?
beta-endorphins
49
delta receptor is for?
enkephalins
50
kappa opioid receptor is for?
dynorphin
51
opioid mechanism
Open K+ channels, close Ca2_ channels --> decreased synaptic transmission + inhibit release of ACh + NE + 5-HT + glutamate + substance P.
52
opioid GI use
anti-diarrheal
53
other use for opioid analgesics?
Acute pulmonary edema
54
opioid AE's
1) addiction 2) respiratory depression 3) constipation 4) miosis 5) additive CNS depression with other drugs
55
meperidine is unique in AE's among opioid analgesics because....
Causes mydriasis rather than mitosis.
56
tolerance and opioids
does not develop to *miosis and constipation.