Neuro II Flashcards
acetylcholine location of synthesis
Basal nucleus of Meynert
acetylcholine and neuro conditions
Decreased in AD and HD, Increased in PD
Dopamine location of synthesis
1) ventral tegmentum
2) SNpc (substantia nigra pars compacta)
GABA location of synthesis
Nucleus Accumbens
Norepinephrine location of synthesis
Locus ceruleus
Serotonin location of synthesis
Raphe nucleus
Serotonin altered in…
1) Down in anxiety
2) Down in depression
3) Increased in PD
What forms the BBB?
1) tight junctions between nonfenestrated capillary endothelial cells.
2) basement membrane
3) astrocyte foot processes
glucose transport through BBB
Carrier-mediated transport
amino acid transport through BBB
carrier-mediated transport
How do you determine passage through BBB?
If a substance is non polar/lipid solute it will cross rapidly via diffusion.
Neurohypophysis structure and function
Fenestrated capillaries and no BBB, which permits neurosecretory products to enter circulation.
OVLT significance
Organum vasculosum of the lamina terminals. Specialized region of brain with no BBB and fenestrated capillaries used for osmotic sensing. Senses change in osmolarity
Area postrema signficance
Specialized region of brain with no BBB and fenestrated capillaries that detects noxious stimuli and induces vomiting.
vasogenic edema
Destruction of endothelial cell tight junctions due to infarction and/or neoplasm and leading to edema.
Hypothalamus regulates
1) thirst and water balance
2) hunger
3) ANS regulation
4) temperature regulation
5) sexual urges
area postrema location
medulla
ADH from…
supraoptic nucleus
oxytocin from…
paraventricular nucleus
Common cause of destruction to ventromedial area…
craniopharyngioma
anterior hypothalamus innervation
parasympathetic (cooling is a PS function)
posterior hypothalamus innervation
sympathetic (heating is a sympathetic function)
suprachiasmatic nucleus regulates…
circadian rhythm