ID 20

Question 1

IFN-alpha uses

Answer 1

1) Chronic hep B and C
2) Kaposi
3) hairy cell leukemia
4) condyloma acuminatum
5) RCC
6) malignant melanoma

Question 2

IFN-gamma use

Answer 2

CGD

Question 3

Interferons AE’s

Answer 3

1) Flu-like symptoms
2) depression
3) neutropenia
4) myopathy

Question 4

ribavirin MOA

Answer 4

inhibits synthesis of guanine nucleotides by competitively inhibiting inosine monophosphate dehydrogenase

Question 5

ribavirin AE’s

Answer 5

1) hemolytic anemia

2) severe teratogen

Question 6

Sofosbuvir

Answer 6

Inhibits HCV RNA-dependent RNA polymerase acting as a chain terminator.

Question 7

Sofosbuvir AE’s

Answer 7

Fatigue
headache
nausea

Question 8

Sofosbuvir caveat

Answer 8

NEVER use as mono therapy; use for chronic HCV in combination with ribavirin +/- peg interferon alpha

Question 9

simeprevir MOA

Answer 9

HCV protease inhibitor; prevents viral replication

Question 10

simeprevir use

Answer 10

chronic HCV in combination with ledipasvir

Question 11

ledipasvir MOA

Answer 11

NS5A inhibitor

Question 12

simeprevir AE’s

Answer 12

1) photosensitivity

2) rash

Question 13

what is disinfection?

Answer 13

reduction of pathogenic organisms to safe levels.

Question 14

what is sterilization?

Answer 14

inactivation of self-propagating biological entities

Question 15

sporicidal infection control techniques?

Answer 15

1) hydrogen peroxide

2) autoclave and iodine/iodophors may be

Question 16

chlorhexidine MOA

Answer 16

denatures proteins + disrupts cell membranes

Question 17

hydrogen peroxide MOA

Answer 17

free radical oxidation

Question 18

iodine and iodophors MOA

Answer 18

halogenation of DNA, RNA, and proteins.

Question 19

clarithromycin why avoid in pregnancy?

Answer 19

embryotoxic