Neuroscience Week 6: Causes of Seizures

Question 1

Categories of seizures cause

2 listed

Answer 1

Provoked seizures

Unprovoked seizures

Question 2

Provoked seizures AKA

Answer 2

Acute symptomatic seizures

Question 3

Provoked seizures caused by?

4 listed

Answer 3

• medical/metabolic condition (which affects the brain)
• Acute CNS injury
• Medication
• Toxic insult

Question 4

Provoked seizures onset timeline

Answer 4

occur at the timoe or, withing close temporal relation to, the medical illness or insulting event

Question 5

Unprovoked seizures features

Answer 5

Epilepsy = recurrent unprovoked seizures

Question 6

Provoked seizures treatment

Answer 6

Treat the underlying cause or remove the provocation

Question 7

Unprovoked seizures treatment

Answer 7

• if the first unprovoked seizure (often no treatment) because typically doesnt recurr
• if recurrent firsline of treatment = antiepileptic drugs

Question 8

Some causes of provoked seizures

Answer 8

Question 9

More causes of provoked seizures

Answer 9

Question 10

Question 8

Answer 10

B. Provoked most likely due to an antidepressant

Question 11

CNS- direct neuronal injury causes of epilepsy (acquired)

5 listed

Answer 11

Question 12

Congenital/ genetic causes of epilepsy

Answer 12

• cortical migration abnormalities, heterotopias, cortical dysplasias
• genetics/channelopathies

Question 13

Genetics of epilepsy overview

Answer 13

Question 14

The scope of genetic defects in epilepsy

3 listed

Answer 14

Question 15

Defects of neuronal metabolism that can cause seizures

Answer 15

metabolic problems are often linked to cause of seizures

Question 16

Defects of network development

3 listed

Answer 16

cell proliferation and specification - problems with division of cells and appropriate neurons

neuronal migration - neurons moving to apporpriate locations and levels

Late cortical organization - problems of organization in the cortices

Question 17

Defects of network development: cell proliferation and specification examples

2 listed

Answer 17

focal cortical dysplasia - poorly formed not fully functioning neurons and tend to be epileptogenic

Tuberous sclerosis - unusall growths called tubers that are epileptogenic

Question 18

Defects of network development: Neuronal migration examples

Answer 18

Lissencephaly - smooth brain, not appropriate migration of cells

gray matter heterotopia - similar migration of cell defect, islands of cell bodies that do not successfully migrate

Question 19

Defects of network development: late cortical organization examples

Answer 19

Polymicrogyria - poorly formed cortex

Question 20

Defects of membrane and synaptic signaling

Answer 20

• ion channels
• signaling molecules

Question 21

Epidemiology of seizures and causality

Answer 21

what ages causes of seizures caused by which etiologies

Question 22

Children common causes of seizures

5 listed

Answer 22

• genetic
• infection
• trauma
• congenital
• metabolic

Question 23

Adults common causes of seizures

4 listed

Answer 23

• Tumors
• trauma
• stroke
• Infection

Question 24

Elderly common causes of seizures

5 listed

Answer 24

• Stroke
• tumor
• trauma
• metabolic
• infection

Question 25

summary1/3

Answer 25

summary 2/3

Question 26

summary 3/3

Answer 26

Question 27

malinger definition

Answer 27

exaggerate or feign illness in order to escape duty or work.