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Neuroscience > Neuroscience Week 5: Adrenergic Phys 1 > Flashcards

Neuroscience Week 5: Adrenergic Phys 1 Flashcards

1
Q

Stimulation of the heart with sympathetics

A
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2
Q

Norepinephrine is a ________ and chemical structure

A
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3
Q

Norepinephrine Synthesis

Know the precursors and enzymes

A
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4
Q

Norepinephrine Synthesis and release and reuptake

A
  • Vesicular release
  • NET uptake
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5
Q

Norepinephrine Signal termination

A

Norepinephrine is taken back up

  • nerve terminals reuse it
  • targets get rid of it
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6
Q

Norepinephrine and epinephrine Terminology

A
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7
Q

Norepinephrine is used primarily by?

A

sympathetic postganglionics on α and β adrenergic receptors

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8
Q

Sympathetic Target organ System effects

A
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9
Q

Adrenergic Receptor mechanisms

A

They use second messengers

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10
Q

Phospholipase C Pathway and adrenergic receptors

A

α-1 receptors

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11
Q

α-1 receptors mechanism

A

Noreepipenphrine

phospholipase C

present on smooth muscle (cardiovascular), Iris

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12
Q

α-1 receptors Location

A

present on smooth muscle (cardiovascular), Iris

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13
Q

Adrenergic Receptor type for pupil dilation/constriction

A

α-1 receptors on the Iris for pupil dilation (iris dilation)

M3 receptor for pupil constriction

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14
Q

Parasympathetic M3 receptor vs adrenergic α-1 receptors

A
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15
Q

Receptor to speed up the heart

A

β1 adrenergic receptor

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16
Q

β1 adrenergic receptor Mechanism

A
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17
Q

β1 adrenergic receptor Effects

A
  • ↑ cAMP
  • ↑ PKA
  • leads to ↑Ca2+ influx
  • EXCITATION
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18
Q

β2 adrenergic receptor Effects

A

INHIBITION of smooth muscle

↓Ca2+ influx

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19
Q

Adrenergic receptors on cardiac muscle and smooth muscle

A
  • excitatory in cardiac
  • inhibitory of smooth muscle
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20
Q

Major adrenergic receptors

A
  • α1 adrenergic receptor Effects
  • α2 adrenergic receptor Effects
  • β1 adrenergic receptor Effects
  • β2 adrenergic receptor Effects
  • β3 adrenergic receptor Effects
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21
Q

Cardiac Muscle Stimulation: second messenger coupling

A

↑Adenylate Cyclase

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22
Q

Cardiac muscle inhibition: second messenger coupling

A

↓adenylate cyclase

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23
Q

Smooth Muscle Stimulation: second messenger coupling

A

↑phospholipase C

24
Q

Smooth muscle Inhibition: second messenger coupling

A

↓phospholipase C

25
Q

Gland stimulation: second messenger coupling

A

↑phospholipase C

26
Q

Glands inhibitory second messenger coupling

27
Q

Group Challenge

28
Q

Adrenergic receptor Overview

29
Q

Adrenergic receptors: Identify second messenger, targets and effects

30
Q

Which receptors go where?

31
Q

Renal sympathetic function

A
  • make the fundus bigger (relax the fundus)
  • trigone needs to constrict
32
Q

Question 1

33
Q

Which receptors?

34
Q

α2 adrenergic receptor

A

self regulated release of Norepinephrine

35
Q

Identify receptor second messenger, targets and effects

36
Q

Sweat glands neurotransmitter

A

Sympathetic postganglionic that release Ach

37
Q

Sympathetic postganglionic that release Ach

A

Sweat glands

&

a few fibers to blood vessels in skeletal muscles and some vessels of the heart

38
Q

Sympathetic innervation of extremities

39
Q

Atropine and sweat glands

A

block sweat glands making you hot blocking a sympathetic response not a parasympathetic one

40
Q

Dopamine receptors on renal Keep in mind

A

para and sympathetics don’t secrete dopamine onto the renal vasculature

it is coming from the proximal tubule

41
Q

Termination of Norepinephrine Action

3 listed

A

MAO-A and MAO-B

42
Q

Epinephrine is a ________ and chemical structure

43
Q

Epinephrine is secreted by?

A

Adrenal glands

44
Q

Sympathetic stimulation of adrenals

45
Q

General actions of epinephrine

A

there is some preference

46
Q

Actions of epinephrine: In general

47
Q

Actions of epinephrine: Metabolic

48
Q

Actions of epinephrine: Cardiovascular

49
Q

Actions of epinephrine: Pulmonary

50
Q

Actions of epinephrine: GI

51
Q

Adrenergic Physiology Summary

52
Q

α2 caveat

A

presynaptic

53
Q

Norepinephrine Precursor

54
Q

Norepinephrine intermediates

A
  • L-Dopa
  • Dopamine
55
Q

Norepinephrine synthesis precursor to intermediates

A

Tyrosine

↓

L-DOPA

↓

Dopamine

↓

Norepinephrine

56
Q

Norepinephrine synthesis enzymes

A
  • Tyrosine hydroxylase
  • Aromatic acid decarboxylase
  • Dopamine β hydroxylase

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