Neuroscience Week 5: Adrenergic Phys 1 Flashcards by Jay Sandoval

Q

Stimulation of the heart with sympathetics

A

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Q

Norepinephrine is a ________ and chemical structure

A

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Q

Norepinephrine Synthesis

Know the precursors and enzymes

A

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Q

Norepinephrine Synthesis and release and reuptake

A

Vesicular release
NET uptake

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Q

Norepinephrine Signal termination

A

Norepinephrine is taken back up

nerve terminals reuse it
targets get rid of it

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Q

Norepinephrine and epinephrine Terminology

A

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Q

Norepinephrine is used primarily by?

A

sympathetic postganglionics on α and β adrenergic receptors

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Q

Sympathetic Target organ System effects

A

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Q

Adrenergic Receptor mechanisms

A

They use second messengers

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Q

Phospholipase C Pathway and adrenergic receptors

A

α-1 receptors

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Q

α-1 receptors mechanism

A

Noreepipenphrine

phospholipase C

present on smooth muscle (cardiovascular), Iris

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Q

α-1 receptors Location

A

present on smooth muscle (cardiovascular), Iris

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Q

Adrenergic Receptor type for pupil dilation/constriction

A

α-1 receptors on the Iris for pupil dilation (iris dilation)

M3 receptor for pupil constriction

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Q

Parasympathetic M3 receptor vs adrenergic α-1 receptors

A

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Q

Receptor to speed up the heart

A

β1 adrenergic receptor

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Q

β1 adrenergic receptor Mechanism

A

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Q

β1 adrenergic receptor Effects

A

↑ cAMP
↑ PKA
leads to ↑Ca²⁺ influx
EXCITATION

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Q

β2 adrenergic receptor Effects

A

INHIBITION of smooth muscle

↓Ca²⁺ influx

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Q

Adrenergic receptors on cardiac muscle and smooth muscle

A

excitatory in cardiac
inhibitory of smooth muscle

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Q

Major adrenergic receptors

A

α1 adrenergic receptor Effects
α2 adrenergic receptor Effects
β1 adrenergic receptor Effects
β2 adrenergic receptor Effects
β3 adrenergic receptor Effects

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Q

Cardiac Muscle Stimulation: second messenger coupling

A

↑Adenylate Cyclase

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Q

Cardiac muscle inhibition: second messenger coupling

A

↓adenylate cyclase

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Q

Smooth Muscle Stimulation: second messenger coupling

A

↑phospholipase C

Q

Smooth muscle Inhibition: second messenger coupling

A

↓phospholipase C

Gland stimulation: second messenger coupling

↑phospholipase C

Glands inhibitory second messenger coupling

N/A

Group Challenge

Adrenergic receptor Overview

Adrenergic receptors: Identify second messenger, targets and effects

Which receptors go where?

Renal sympathetic function

* make the fundus bigger (relax the fundus) * trigone needs to constrict

Question 1

B.

Which receptors?

α2 adrenergic receptor

self regulated release of Norepinephrine

Identify receptor second messenger, targets and effects

Sweat glands neurotransmitter

Sympathetic postganglionic that release Ach

Sympathetic postganglionic that release Ach

Sweat glands & a few fibers to blood vessels in skeletal muscles and some vessels of the heart

Sympathetic innervation of extremities

Atropine and sweat glands

block sweat glands making you hot blocking a sympathetic response not a parasympathetic one

Dopamine receptors on renal Keep in mind

para and sympathetics don't secrete dopamine onto the renal vasculature it is coming from the proximal tubule

Termination of Norepinephrine Action 3 listed

MAO-A and MAO-B

Epinephrine is a ________ and chemical structure

Epinephrine is secreted by?

Adrenal glands

Sympathetic stimulation of adrenals

General actions of epinephrine

there is some preference

Actions of epinephrine: In general

Actions of epinephrine: Metabolic

Actions of epinephrine: Cardiovascular

Actions of epinephrine: Pulmonary

Actions of epinephrine: GI

Adrenergic Physiology Summary

α2 caveat

presynaptic

Norepinephrine Precursor

Tyrosine

Norepinephrine intermediates

* L-Dopa * Dopamine

Norepinephrine synthesis precursor to intermediates

Tyrosine ↓ L-DOPA ↓ Dopamine ↓ Norepinephrine

Norepinephrine synthesis enzymes

* Tyrosine hydroxylase * Aromatic acid decarboxylase * Dopamine β hydroxylase