Neuroscience Week 5: Autonomic Nervous System: Parasympathetic Functional Anatomy Flashcards
Organ systems parasympathetic response
Oculomotor parasympathetic actions & associated ganglia
autonomic regulation of pupil diameter
Circular fibers of the eye
- parasympathetic control
- smooth muscle
- constricts iris
- sphincter pupillae
Radial Fibers of eye
- sympathetic control
- dilator pupillae
- smooth muscle
- dilates iris
Parasympathetics of Facial nerve
- lacrimal gland tear production
- submandiubular salivary gland
- sublingual salivary secretion
Through the pterygopalatine ganglion and submandibular ganglion
Parasympathetics of glossopharyngeal nerve and associated ganglia
- otic ganglion
- Parotid gland
- glands of the posterior tongue
Parasympathetic ganglion of facial nerve
2 listed
Pterygopalatine ganglion
and
submandibular ganglion
Parasympathetic ganglion of glossopharyngeal nerve
Otic ganglion
Parasympathetic ganglion of Vagus nerve
5 listed target tissues
to stomach
to heart
to intestines
to lungs
to liver
*SHILL*
Basic functional structure of parasympathetics
- cranio-sacral origins
- long preganglionics
- very short postganglionics
Sacral parasympathetic innervation origin and targets
- comes out of cauda equina
- Left colic flexure of large intestines
- Bladder
- Penis
- Clitoris
Question 1
C
Difficulty with completely voiding during a trip to the bathroom
Sacral parasympathetic innervation outflow
The left colic flexure separates what?
cranial parasympathetic innervation from sacral splanchnic innervation
vagal stimulation of the heart
Otto Loewi’s Experiment
neurotransmitters of parasympathetic post ganglionics
Acetylcholine in parasympathetics
Parasympathetic nervous system
How do muscarinic ACh receptors transduce their signal?
work through second messengers
Muscarinic Receptor subtypes
- M1
- M2
- M3
- M4
- M5
Phospholipase C system
gets calcium to increase inside cells
Acetylcholine Receptors Slow-sustained type
Muscarinic metabotropic
Acetylcholine receptor fast short-lived type
Nicotinic ionotropic
M3 receptors function and location
Smooth muscle
M2 Receptor
- Gi coupled
- inhibits adenylate cyclase
- cardiac inhibition
Parasympathetic receptor on the bladder
M3
on the fundus and external sphincter
Muscarinic Receptor subtypes overview
M1 Second Messenger
- Stimulation of Phospholipase C
M1 Targets
- CNS
- Enteric Nervous System
M1 Effects
- Undefined
- Gastric Acid Secretion
M2 Second Messenger
- Inhibition of Adenylate Cyclase
- Activation of K+ channels
M2 Targets
Heart
M2 Effects
Inhibition
M3 Second Messenger
- Stimulation of Phospholipase C
M3 Targets
- Smooth muscle
- Secretory Glands
M3 Effects
- Contraction
- Secretion
M4 Second Messenger
Inhibition of Adenylate Cyclase
M4 targets
?
M4 Effects
?
M5 Second Messenger
Stimulation of Phospholipase C
M5 Targets
CNS
M5 Effects
Undefined
Parasympathetic summary
Parasympathetic preganglionic origins
which nerves?
- Craniosacral origins
- Cranial nerves VII, III, IX and X
- Cauda equina sacral origins
- S2-S4
