Neuroscience Week 5: Adrenergic Phys 2

Question 1

Adrenergic Receptors second messenger, targets and effects

Answer 1

Question 2

α1 agonist example

Answer 2

Phenylephrine

Question 3

α2 agonist example

Answer 3

Clonidine

Question 4

Adrenergic receptor type and organ system effects

Answer 4

Question 5

α2 agonist mechanism

Answer 5

agonist at α2 receptor decrease excitation-secretion coupling causes even less release of Norepinephrine

Question 6

Question 1

Answer 6

Phenylephrine Nasal Spray

Question 7

Clonidine historical use

Answer 7

Systemic hypertension

Question 8

α antagonist examples

Answer 8

• Phentolamine
• Prazosin

Question 9

Phentolamine Receptor target

Answer 9

non-selective α1/α2

Question 10

Phentolamine uses

Answer 10

Some use in control of hypertension

Question 11

Prazosin Receptor target

Answer 11

α1 antagonist

Question 12

Prazosin Uses

Answer 12

Question 13

Benign Prostatic Hyperplasia description

Answer 13

Question 14

Question 2

Answer 14

D.

Question 15

BPH AKA

Answer 15

Benign Prostatic Hyperplasia

Question 16

Treatment of BPH

Answer 16

Prazosin

Question 17

β Receptor Drug Agonists examples

Answer 17

‘enol’

‘erol’

Question 18

β Receptor Drug Antagonists examples

Answer 18

‘olol’

Question 19

β Agonists to know

Answer 19

• Isoproterenol
• Albuterol

Question 20

Isoproterenol receptor target

Answer 20

non-selective β1/β2

Question 21

Albuterol Receptor target

Answer 21

some β2 selectivity

Question 22

non-selective β agonists effects

Answer 22

↑HR

↓relax smooth muscle

Question 23

Question 3

Answer 23

E.

Question 24

β receptor agonist side effects in asthma therapy

3 listed

Answer 24

• CV effects
• Tremor
• Hypokalemia

Question 25

β receptor agonist actions in asthma therapy

Answer 25

Question 26

β receptor antagonist examples

Answer 26

Propranolol

Atenolol

Question 27

Propranolol Receptor target

Answer 27

non-selective β1/β2

Question 28

Atenolol Receptor target

Answer 28

selective β1

Question 29

β1 receptor antagonist effects

Answer 29

Opposite of this so decreases excitation

prevents this pathway from getting turned on

Question 30

β receptor antagonists effects in hypertension

Answer 30

Question 31

Resting tone

Answer 31

Question 32

β receptor antagonist in hypertension Adverse effects

Answer 32

Question 33

Indirect acting sympathomimetics examples

4 listed

Answer 33

Question 34

Amphetamine MOA Effects

Answer 34

Question 35

Amphetamine MOA

Answer 35

more NE not packaged in vesicles and so more norepinephrine is being released

Question 36

Amphetamine Therapeutic Uses

3 listed

Answer 36

Question 37

Cocaine MOA

Answer 37

disrupts sympathetic transmission

binds to transporter and prevents reuptake of NE

Question 38

Cocaine MOA

Answer 38

cocaine doesn’t modify nerve activity, cocaine doesn’t cause release but enhances systems already in use by preventing NE reuptake

Question 39

Cocaine Therapeutic Uses

Answer 39

• ENT surgery
• limits bleeding and local anesthetic effect

Question 40

Cocaine Deleterious effects

Answer 40

• Seizures
• Hypertensive crisis-cerebral hemorrhage
• Cardiac arrhythmias
• Myocardial ischemia (in situ thrombosis or coronary spasm)

Question 41

Tyramine MOA

Answer 41

causes release of catecholamines from vesicles, increasing synaptic concentrations

works like amphetamine

Question 42

Tyramine found where

Answer 42

tyrosine metabolism - pickled foods or sausage or smelly cheese

Question 43

Tyramine contraindicated in

Answer 43

people taking MAOI’s

Question 44

Tyramine Therapeutic Relevance

3 listed

Answer 44

Question 45

Ephedrine MOA

Answer 45

causes release of catecholamines from vesicles and directly activates adrenergic receptors

Question 46

Ephedrine was used antiquity for?

Answer 46

Treatment of asthma

Question 47

Ephedrine therapeutic relevance

Answer 47

Question 48

Ephedrine Abuse potential

Answer 48

Question 49

Adrenergic Pharmacology Summary

Answer 49