MS treatment

Question 1

3 different types of treatment

Answer 1

• severity of relapses with steroids
• symptoms (urinary control, spasticity, pain etc)
• immunomodulation (disease modifying therapy DMT)

Question 2

waar demyelination tijdens RRMS

Answer 2

vooral in white matter

Question 3

waar demyelination tijdens SRMS

Answer 3

vooral in grey matter

Question 4

a lot of inflammation leads to risk of…

Answer 4

a lot of neurodegeneration

Question 5

for most treatments…

Answer 5

we dont know exactly how it works

Question 6

infratentorial

Answer 6

below the cerebellum

Question 7

voor dissemination in time…

Answer 7

dus meerdere mri scans nodig!

Question 8

how would you choose a type of DMT?

Answer 8

• effectiveness
• mode of administration
• side effects
• costs

Question 9

effectiveness

Answer 9

hoeveel nieuwe lesions en hoeveel nieuwe relapses?

Question 10

highest efficacy

Answer 10

natiluzumab, alemtuzumab, acrelizumab, cladribine

Question 11

wat zijn injecties

Answer 11

interferon en Glatiramer acetate

Question 12

wat zijn alle zumabs

Answer 12

IV

Question 13

interferons en glatiramer acetate

Answer 13

lage effectiviteit en lage risks. skin reactions + flu like

Question 14

teriflunomide

Answer 14

hair loss

Question 15

JC virus is

Answer 15

john cunningham virus, causes multifocal leukoencephalopathy

Question 16

natiluzumab

Answer 16

montly injections, high risks, risk of JC

Question 17

first line treatments

Answer 17

IFNb
GA
Teriflunomide
DMF
ozanimod

Question 18

wat als first line niet werkt

Answer 18

switchen between lines, anders naar tweede line

Question 19

wat is tweede line?

Answer 19

Fingolimod
Natalizumab
Alemtuzumab
Ocrelizumab
cladribine

Question 20

als je jc negatief bent kan je …

Answer 20

natalizumab gebruiken

Question 21

en als je positief bent :

Answer 21

dan niet natalizumab gebruiken! want die patienten meer risico op multifocale leukoencefalopathie

Question 22

wie maakt de beslissing?

Answer 22

de patient!

Question 23

werking interferons

Answer 23

Interferon beta: Cytokine, move immune response from Th1 to Th2

Question 24

werking glatiramer acetate

Answer 24

Glatiramer acetate: Set of random proteins similar to myelin, Th1 to Th2