Genetics Flashcards
missense mutation
replacement of a single nucleotide leads to 1 different aminoacid
nonsense mutation
aminoacid changes into a nonsense mutation, meaning that the protein gets cut off –> korter
insertion mutation
an insertion leads to all the aminoacids after that one to change
deletion mutation
changing all the aminoacids after this one
duplication
a piece of chromosome gets duplicated during the cell division
frameshift mutation
A frameshift mutation is a genetic mutation caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read.
repeat expansion mutation
een triplet wordt gedupliceerd, waardoor er dus 2 van het aminozuur is
comt doet…
inactivates dopmine, adrenaline, noradrenaline
maoa
regulate serotonin
maoa relationship with CD
lagere maoa betekent meer kans op conduct disorder
maoa is related to …
reactive aggression
5htt gene
reduction of transcription of the 5htt gene leads to an aggressive phenotype
how to test animal aggression
with the resident intruder test
twee soorten muizen
AggressiveBALB/cJ and non-aggressive BALB/cByJ mice
waar lijken de BALB/cj muizen op?
op kinderen met conduct disorder en CU traits
