Genetics Flashcards
missense mutation
replacement of a single nucleotide leads to 1 different aminoacid
nonsense mutation
aminoacid changes into a nonsense mutation, meaning that the protein gets cut off –> korter
insertion mutation
an insertion leads to all the aminoacids after that one to change
deletion mutation
changing all the aminoacids after this one
duplication
a piece of chromosome gets duplicated during the cell division
frameshift mutation
A frameshift mutation is a genetic mutation caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read.
repeat expansion mutation
een triplet wordt gedupliceerd, waardoor er dus 2 van het aminozuur is
comt doet…
inactivates dopmine, adrenaline, noradrenaline
maoa
regulate serotonin
maoa relationship with CD
lagere maoa betekent meer kans op conduct disorder
maoa is related to …
reactive aggression
5htt gene
reduction of transcription of the 5htt gene leads to an aggressive phenotype
how to test animal aggression
with the resident intruder test
twee soorten muizen
AggressiveBALB/cJ and non-aggressive BALB/cByJ mice
waar lijken de BALB/cj muizen op?
op kinderen met conduct disorder en CU traits
what did they find with the mice?
minder trials nodig -> cognitief meer flexibel, maar leren minder goed onder punishment.
what did they find in relation to less GABA by these mice?
increased expression of the gene coding for GABA breakdown (gamma vinyl transferase expression) in the ACC and MCC of BALB/cJ mice
what does tryptophan do
Tph2 (Trytophan Hyroxylase) catalyses the production of brain serotonin
tph2 knockout mice zijn…
more aggressive, less anxiety
