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Histology > Lymphoid Tissue Part 2 > Flashcards

Lymphoid Tissue Part 2 Flashcards

1
Q

largest lymphoid organ in the body

A

spleen

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2
Q

immune functions of the spleen (4)

A

• b-& t-cell replication, manufacture of Ab, Ag removal
• Removes particulate matter & aged or defective rbc’s
from circulation via phagocytosis
• Recycles Fe from Hb
• Hemopoiesis in fetus

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3
Q

removal of spleen

A

splenectomy

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4
Q

if the spleen is removed, function is taken over by (2)

A

liver and bone marrow

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5
Q

Dense, fibro-elastic outer capsule contains

A

smooth Mm cells

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6
Q

mooth Mm cells are important in

A

splenic contraction in some species

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7
Q

smooth Mm cells act as a reservoir for

A

rbc’s

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8
Q

Characteristic large, thick bands of dense connective tissue — extend into body of spleen

A

trabeculae

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8
Q

Characteristic large, thick bands of dense connective tissue — extend into body of spleen

A

trabeculae

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9
Q

Characteristic large, thick bands of dense connective tissue — extend into body of spleen

A

trabeculae

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10
Q

Characteristic large, thick bands of dense connective tissue — extend into body of spleen

A

trabeculae

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11
Q

trabecular contain trabecular (2)

A

Aa & Vv

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12
Q

Unlike lnn, spleen lacks (2)

A

cortex & medulla

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13
Q

Bulk of spleen composed of spongy matrix of

A

red pulp

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14
Q

Within red pulp are (2)

A

pulp cords & sinusoids

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15
Q

cords of Bilroth

A

pulp cords

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16
Q

Sinusoids contain mostly

A

blood

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17
Q

Pulp cords are more —, contain large #’s of (2)

A

cellular

macrophage and lymphocytes

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18
Q

Pulp cords supported by connective tissue skeleton of (2)

A

reticular cells & reticular fibers

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19
Q

scattered throughout red pulp are discreet nodules of

A

white pulp

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20
Q

white pulp contains large #’s of

A

wbc’s

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21
Q

Areas of white pulp =

A 
follicular areas+/-germinal 
centers (contain 1’ b-cells), 
with central A in middle and 
surrounded by thin, 
basophilic mantle zone
surrounded by paler 
marginal zone
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22
Q

white pulp functions as a site of (2)

A

Ag presentation, phagocytosis

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23
Q

white pulp contains large numbers of (3)

A

macrophages
plasma cells
t helper cells

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24
Q

Splenic nodules

A

enlarged germinal centers visible to naked

eye

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25
Q

Central Aa surrounded by — rather than b-cells form

A

t-cells

periarteriolar lymphatic sheaths (PALS)

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26
Q

periarteriolar lymphatic sheaths (PALS) lack — — because

A

germinal centers, because minimal t-cell proliferation

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27
Q

periarteriolar lymphatic sheaths (PALS) are less — — in humans than other species & require
— — to make positive ID

A

well developed

immunohistochemical staining

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28
Q

PALS is often used interchangeably with

A

1’ follicles in white pulp

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29
Q

Branches of splenic A enter white pulp within trabeculae via

A

trabecular Aa

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30
Q

Branches of splenic A enter white pulp within trabeculae via trabecular Aa, branch & form

A

central Aa to white pulp

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31
Q

Central Aa continue into red pulp, branch into

A

perpendicular penicillar Aa

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32
Q

perpendicular penicillar Aa branch into

A

arterioles

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33
Q

arterioles terminate in

A

2-3 sheathed capillaries

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34
Q

sheathed capillaries

A

blind ending capillaries, lack endothelial lining

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35
Q

sheathed capillaries are surrounded by

A

macrophages

36
Q

Forms a non-continuous

A

perivascular sheath, or cuff

37
Q

perivascular sheath, or cuff acts as part of filtering mechanism, active in

A

phagocytosis

38
Q

Blood cells leave sheathed capillaries via —, enter sinuses in — —

A

diapedesis

red pulp

39
Q

Sinusoids lined by endothelial cells called

A

stave cells

40
Q

Endothelial slits between stave cells allow

A

free passage of blood cells

41
Q

Blood drains out of spleen via —, empties into —

A

trabecular Vv

splenic V

42
Q

— — model of spleen

A

Open circulation

43
Q

palatine tonsil

A 
Paired structures located at 
junction of oral & pharyngeal 
cavities, within tonsillar crypts, 
between anterior& posterior 
tonsilar pillars(= palatoglossal& 
palatopharyngeal arches)
44
Q

Lingual tonsils

A

present at base of
tongue & pharyngeal tonsils (=adenoids) in nasopharynx,
associated with Eustacian tubes

45
Q

Palatal, lingual, & pharyngeal

tonsils collectively referred to as

A

Waldeyer’s ring

46
Q

Waldeyer’s ring forms a ring of

A

immunologic protection ~ GI & respiratory tracts

47
Q

Palatal & pharyngeal tonsils

collectively referred to as

A

NALT

nasal associated lymphoid tissue

48
Q

palatine tonsil is similar to lnn, but

A

unencapsulated

49
Q

Base of tonsil supported by cup-shaped, collagenous —

A

hemicapsule

50
Q

palatine tonsil cortex and medulla

A

none

51
Q

— — scattered throughout parenchyma

A

Lymphoid follicles

52
Q

lymphoid follicles may include

A

germinal centers

53
Q

Luminal surface of palatine & lingual tonsils covered by characteristic

A

stratified squamous nonkeratinized epithelium

54
Q

Luminal surface of palatine & lingual tonsils covered by characteristic stratified squamous nonkeratinized epithelium—invades tonsil, forming

A

blind-ended tonsilar crypts

55
Q

Lymph node

A

cortex with 1’ & 2’ follicles & medulla

with medulary cords & sinusoids

56
Q

Thymus

A

mostly t-cells, not b-cells; Hassal’s

corpuscles; cortex & medulla present

57
Q

Spleen

A

robust capsule & trabeculae; nocortex &

medulla, red & white pulp instead

58
Q

Palatine tonsil

A

hemicapsule & skin-like epithelium

with crypts; nocortex & medulla

59
Q

appendix

A

Blind-ended sac, vestigial

cecum

60
Q

Atrophies in adults; contains

mostly

A

b-cells

61
Q

Important digestive organ in

—; used for — —

A

herbivores
bacterial
fermentation

62
Q

inflammation of appendix

A

appendicitis

63
Q

surgical removal of appendix

A

appendectomy

64
Q

MALT in gut

A

GALT

65
Q

MALT in respiratory tract

A

BALT

66
Q

T in pharynx

A

NALT

67
Q

Diffuse, unencapsulated lymphoid
aggregates associated with
— —

A

mucosal surfaces

68
Q

Located in subepithelial connective

tissue of

A

lamina propria

69
Q

MALT contains mainly

A

B cells

70
Q

MALT produces

A

1’ IgA

71
Q

IgA

A

secretory IgA

72
Q

MALT may contain

A

germinal centers, similar to lnn

73
Q

Samples — material, produces —, secretes –

A

antigenic
lymphoblasts
Ab

74
Q

MALT in gut contains specialized M-cells called

A

squamoid

enterocytes

75
Q

squamoid

enterocytes are located in

A 
surface epithelium with microfolds
on surface (notmicrovilli)
76
Q

MALT is responsible for (2)

A

Ag sampling & transfer from gut lumen into

lymphoid follicles

77
Q

MALT formed during

A

fetal development

78
Q

MALT distribution (age wise)

A

maximum in childhood, progressively

atrophies with age

79
Q

Peyers patches

A

Special type of MALT scattered throughout small intestine

80
Q

where are peyers patches most common and least common?

A

most common in ileum, least common in duodenum

81
Q

Peyes patches project into lumen of gut in dome areas with

A

cuboidal mucosa

82
Q

peyers patches also contain

A

also contain M-cells

83
Q

Peyers patches are histologically similar to

A

MALT

84
Q

Lymphoid aggregates contain large #’s of both

A

b-& t-cells

85
Q

peyer’s patches do not produce appreciable quantities of

A

IgA

86
Q

— — are frequent in Peyers patches

A

Germinal centers

87
Q

Peyers patches are associated with

A

foci of b-cells

Histology (32 decks)

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