Lecture 9 - B cell response/antibodies Flashcards
Humoral immunity
antibody-mediated
why does the plasma cells have more space
needs for endoplasmic reticulum and antibody synthesis
If immature B cells do not find an antigen they
leave the bone marrow
if BCR binds to self-antigen they
are eliminated via apoptosis or undergo receptor editing
If a B cell is still reactive to self antigens following receptor editing they
undergo apoptosis
Central tolerance of B cells refers to
The double-positive system before leaving the bone marrow
Transitional B cells are
B cells that have exited the bone marrow into circulation
Peripheral tolerance of B cells refers to
Single positive system of B cells maturation in the spleen
Transitional B cells with no strong self reaction
mature
what is the final stage of B cell maturation
upregulation of surface IgD
summarize the stages of B cell development
1 - stem cell in bone marrow
2 - pre B cell in lymphoid organs
3 - immature B cell obtain membrane IgM and IgD
4 - mature B cell in secondary organs obtain antigen
5 - plasma cells secrete immunoglobulins
T/F: other species have peyer’s patches but they are not the primary organ like in pigs
True
Fc receptors bind to
the B cell membrane
complement receptors do what
regulate
cytokine receptors do what
co-stimulate and regulate
BCRs consist of
immunoglobin domains
what domain of the BCR is the antigen-binding site
light chains
what are the signal transduction components of BCR
CD79 alpha and beta
how are BCRs and TCRs similar
antigen-specific
respond to epitomes presented in the linear form
How are BCRs different from TCRs
recognize free-floating native (3D) antigen, giving them more binding variety