Lecture 11 - Mucosal Immunology

Question 1

T/F: the mammary gland is considered a mucosal tissue

Answer 1

False - only after pregnancy/during lactation

Question 2

What are some distinct features of mucosal immunity

Answer 2

broad surface area
produce mucins/mucus
immunoglobulins + tolerance inducing dendritic cells
high number of Treg cells
specialized uptakes (M cells)

Question 3

T/F: most pathogens causing human deaths will infect via mucosal surfaces

Answer 3

True

Question 4

Give the function of:

absorptive enterocyte

Answer 4

• microbial and metabolic sensing
• transport of secretory immunoglobulins

Question 5

Give the function of:

Microfold (M) cells

Answer 5

• antigen uptake
• bacterial translocation

Question 6

Give the function of:

Goblet cell

Answer 6

• antigen uptake
• production of mucins

Question 7

Give the function of:

paneth cell

Answer 7

• secretion of AMPs

Question 8

Give the function of:

Tuft cell

Answer 8

• mobilization of type 2 ILCs via IL-25 and eicosanoid release

Question 9

What are the 3 properties of mucins

Answer 9

1. secreted by goblet cells
2. makes mucus sticky
3. provide a framework where molecules of secreted IgA and defensins catch

Question 10

what is the mechanism of action in the:

B defensins

Answer 10

cell membrane disruption

Question 11

summarize the mucosal functions of immunoglobulins

Answer 11

1. secreted IgA binds and neutralizes pathogens and toxins on the surface and endosomally
2. export toxins
3. transport of antigen to DC

Question 12

HEV

Answer 12

high endothelial venules

Question 13

how does the elimination of commensal bacteria allow for pathogenic growth

Answer 13

less good bacteria for resource competition

Question 14

What are the two important T cells

Answer 14

T helper 17
Treg

Question 15

Function of IL-10

Answer 15

immunosuppress

Question 16

At the mucosal level how does the host combat infection

Answer 16

iDC cause Treg differentiation

Question 17

At the lamina propria level how does the host combat infection

Answer 17

mDC activated and T helper 17 cells destroy bacteria