Lecture 8 - Effector T Cell Response Flashcards
What changes are seen in naive T cell priming
1 - forms a stable synapse
2 - increase T cell adhesiveness to APCs
3 - induction of pro-survival signal
4 - increase in metabolic activity
5 - increased transcription
why is it necessary to increase the metabolic activity of T cells
for cell proliferation and production of effector molecules, receptors, integrins, etc.
How is TCR signaling initiated
tyrosine phosphorylation within the cytoplasmic region of immunoreceptors (ITAMs)
summarize:
PLC-y-mediated T-cell activation
- intracellular calcium entry
- activation of RAS
- activation of protein kinase
summarize:
T cell changes after TCR signaling
- increased cell survival
- increased metabolic activity
- increased gene transcription
- increased growth factor production
The T cell receptor has many functional components, some of which are involved in signal transduction, while others are involved in antigen recognition. What two elements are involved in antigen recognition?
TCRa and TCRb
Why are lymph nodes palpable after infection
rapid stromal expansion of immune response
What antigen receptors give rise to CD4 an CD8 T cells
alpha and beta
T/F: cytokines in APCs dictate what T cell differentiate to
True
what are the master regulator transcription factors of CD4+ T cells
T-bet
GATA-4
RORyT
BcI-6
FoxP3
T/F: T helper cells regulate
False - activate
What T helper cell targets extracellular bacteria
TH17
what immune cells do TH17 target for enhanced response
neutrophils
What major cytokines and their actions in TH17
IL17 and IL22
recruit neutrophils
increase cell turnover
direct killing of bacterium on epithelium
What T helper cell targets intracellular bacteria
TH1
what immune cells do the TH1 target for enhanced response
macrophage
What major cytokines and their actions have in TH1
IFN-y
recruit macrophages and increase phagocytotic capability
kills chronically infected cells
What immune cell targets helminth infections
TH2
what immune cells do the TH2 target for enhanced response
eosinophils, mast cells, basophils