Lecture 17 - Avian/Reptile Immunology Flashcards
What are some non-immunological differences between avians and mammals
- no diaphragm
- nucleated RBCs
- choanal slit in palate
What are the primary lymph organs
bursa - B cells
thymus - T cells
What are the secondary lymph organs
spleen, GALT, BALT, harderian
what two immune organs allow for vaccination in eye drops for chickens
conjunctiva associated lymphoid tissue
harderian gland
What enzymes are absent in heterophils
myeloperoxidase
catalase
What do heterophils rely on for pathogen breakdown
oxygen-independent mechanisms
Where are dendritic cells found in the chicken
bursa, thymus, splenic follicles
What PRR is absent in chickens/turkeys
Rig-1-like receptor
What is the equivalent of TLR9 in humans for birds
TLR 15
What is the B complex
MHC complexes in birds
Give the molecules and location of:
MHCI
B-F; all cells
Give the molecules and location of:
MHCII
B-L; APCs
Give the molecules and location of:
MHC IV
B-G; RBCs
T/F: the chicken MHC has a strong association with disease resistance and susceptibility
True
How many class 1 molecules are present in the chicken? how many are present in humans?
2; 6