insomnia

Question 1

z drugs - name them

Answer 1

zopiclone

zolpidem

Question 2

z drugs indications

Answer 2

short term treatment of insomnia

Question 3

MOA z drugs

Answer 3

• similar to Benzos.

- target GABAaR - enhance binding to increase inhibitory effect

Question 4

do z drugs have a shorter or longer half life to benzos

Answer 4

• shorter

Question 5

z drugs SE

Answer 5

• Daytime sleepiness
• rebound insomnia if stopped
• other neuro effects - headache, confused, nightmarres, amnesia
• zopiclone
  = taste disturbance

zolpidem =
- GI upset

Question 6

how long should you use z drugs for and why

Answer 6

no longer than 4 weeks due to risk of dependance. withdrawl if stopped - headache, muscle pain, anxiety.

Question 7

OD z drug symptoms

Answer 7

• drosy
• coma
• resp depression

Question 8

CI to Z drugs

Answer 8

• elderly; more sensitive
  so reduce dose

DO not prescribe in 
- OSA
- Resp muscle weakness
- resp depressionn 
as worsens resp failure

Question 9

interactions with z drugs

Answer 9

• enhance alcohol sedative effect.
• enhace hypotension if with antiHTN
• metabolised by CYP450 so cyp450 - i can increase sedaction and cyp inducers can impair

Question 10

typical doses of zopiclone and zolpidem

Answer 10

• zopiclone = 7.5mg
• zolpidem = 10mg
  halve in elderly

Question 11

route for z drugs

Answer 11

only oral