hypertension

Question 1

name thiazide and thiazide like diuretics

Answer 1

• bendroflumethiazide,

- tld; indapamide, chlortalidone

Question 2

indications for thiazide/TLD

Answer 2

• alternative first line for HTN where CCB unusuable or HF

- add on rx for HTN

Question 3

MOA Thiazide/TLD

Answer 3

• inhibit na/cl co transporter in DCT of nephron - prevents reabsorption of na and water
• initial fall in ECF volume/ overtime compensatory changes reverse this.
• ltm effect by vasodilation

Question 4

SE thiazide/TLD

Answer 4

• Hyponatraemia
• hypokalaemia
• arrhythmias
• increases plasma conc glucose, LDL and triglyceride but net = protective
• impotence

Question 5

CI to Thiazide/TLD

Answer 5

• Hypokalaemia

relative CI

• hyponatraemia
• gout

Question 6

interactions of thiazides/ TLD

Answer 6

• Effects reduced by NSAIDs - low dose aspirin not a concern

Question 7

are thiazides or TLDs better for HTN

Answer 7

• TLD