erectile dysfunction Flashcards
1
Q
PDE5I inhibitors - name
A
sildenafil
2
Q
PED5I Indications
A
- erectile dysfunction
- primary pulmonary hypertension
3
Q
MOA PDE5I
A
- Inhibits PDE5 which is in SM of corpus cavernosum and arteries of the lung.
in the penis; for erection, NO released, which causes CGMP to be produced and cause vasodilatation and engorgement.
PDE5 normally breaks down CGMP. so inhibit = increased conc
only with sexual stimulation
in lungs - pulm vasodilation similarly
4
Q
SE PDE5I
A
- Flushing, headache, dizzy, nasal congestion
- hypotension, tachycardia and palpitations and small icnreased risk of vascular events
- priapism - erection fails to subside
- visual disorders if PDE6 is inhibited in retina
5
Q
CI PDE5I
A
- Stroke
- ACS
- CVD
- if taking other drugs that increase NO (nitrates or nicorandil)
6
Q
avoid Sildenafil in who
A
- Hepatic or renal disease. conc of sild increases by cyp450 inhibitors
- already taking vasodilators; Alpha block (dont take in 4hrs of silden) and CCB
7
Q
Starting dose of sildenafil for erectile dysfunction
A
50mg PO 1hr before sex max OD
8
Q
What is the inly licensed PDE5I for pulmonary hypertension
A
revatio 20mg TDS
9
Q
what delays absorption of PDE5I
A
If taken with food
