constipation

Question 1

name stimulant laxatives

Answer 1

• senna
• bisacodyl
• glycerol suppositories
• docusate

Question 2

indications for stimulant laxatives

Answer 2

constipation or as suppositories for faecal impaction

Question 3

MOA stimulant alxatives

Answer 3

• increase h20 and electrolyte secretion from colonic mucosa = increase volume of colonic content and sitmualtign eprsitalsis
• also direct pro-peristaltic effect
• senna; bacteria in gut produce metabolites of this which act on enteric NS = peristalsis.
• rectal - provokes similar to senna effect but more localised effect so good for impaction
• docusate = stimulant and faecal softener

Question 4

SE stimulant laxatives

Answer 4

• abdo pain and cramping
• diarrhoea
• prolonged use; melanosis coli (reversible pigmentation of intestinal wall)

Question 5

CI stimulant laxatives

Answer 5

• bowel obstruction –> perforation

- rectal; avoid in haemmorhoids or fissures