heart fialure

Question 1

name ARBs

Answer 1

losartan, candesartan, irbesartan

Question 2

ARB indications

Answer 2

• use when ACE=i not tolerated. same indications

Question 3

MOA ARB

Answer 3

• ARB block action of ang II on AT1R. = reduce peripheral resistance (afterload), lowers BP. dialtes efferent glomerualr arteriole = reduces intraglomerular pressure and slows progression of CKD.
• reduce aldosterone = na and h20 excretion. = help to reduce venous return (preload)

Question 4

SE ARB

Answer 4

• Hypotension esp post first dose
• hyperk
• renal failure esp in renal artery stenosis

Question 5

ARB CI

Answer 5

• renala rtery stenosis
• AKI
  caution in
• women who could become pregnant and those breastfeeding
• CKD - lower dose

Question 6

when to stop ARB

Answer 6

In the absence of other causes, the ARB should be stopped if the serum creatinine concentration rises more than 30% or the eGFR falls more than 25%. If serum potassium rises above 5.0 mmol/L, stop other potassium-elevating and nephrotoxic drugs (see Important interactions). If, despite this, it remains above 5.0 mmol/L, reduce the dose of the ARB. If it exceeds 6.0 mmol/L, stop the ARB and seek expert advice.