depression

Question 1

TCA name one

Answer 1

amitryptiline

Question 2

indications TCA

Answer 2

1. second line treatment for mdoerate to severe depression

2. neuropathic pain - unlicensed

Question 3

MOA TCA

Answer 3

• Inhibit neuronal reuptake of 5-HT and NA from cleft. block receptors e.g. msch, h1, alpha 1 and 2 and d2.

Question 4

SE TCA

Answer 4

• dry mouth, constipation, urianry retention, blurred vision = antimuscarinic
• sedation and hypotension due to block h1 and a1
• cardiac; arrythmias and QT and QRs prolonged
• convulsions, hallucinations and mania
• breast changed, sexual dysfunction - EPS
• danger in OD. sudden withdraw = GI upset, neuro and influenza style symptoms and sleep disturbance

Question 5

relative CI TCA

Answer 5

• old
• epilepsy
• CVS
• BPH
• Glaucoma
• constipation prone

Question 6

drug interactions TCA

Answer 6

-MOA-i

Question 7

what dose do u use amitryptilline in depression and also neuroapthic pain

Answer 7

dep= 75mg
pain = 10mg