BPH

Question 1

5 alpha reductase - i indications

Answer 1

• BPH - 2nd line after alpha blockers

Question 2

moa 5 aplha reductase - i

Answer 2

inhibit 5 alpha reductase which converts testosterone into DHT. DHT stimulates prostate growth. but takes a while thats why second line. and added if response is poor or prostate is bulky

Question 3

SE 5 aplha reductase - i

Answer 3

• antiandrogenic; impotence, reduced libido, gynaecomastia and tenderenss of breasts.
• hair growth - can be psoitive or -ve.
• rare = breast cancer if on finasteride

Question 4

CI to 5 alpha reductase- i

Answer 4

• pregnant women should not be exposed or take them as semen during unrpotected sex can give to women. - as male foetus exposure can be bad

Question 5

fiansteride dose

Answer 5

5mg PO OD

Question 6

how logn does it take 5 alpha reductase - i to have full effect

Answer 6

• up to 6 months

Question 7

alpha blocker names

Answer 7

doxazosin
tamsulosin
alfuzosin

Question 8

alpha blocker indications

Answer 8

• BPH - 1st

- add on for treatment resistant HTN

Question 9

Alpha blocker MOA

Answer 9

• blocking = vasodilatation and reduced resistance to bladder outflow

Question 10

SE alpha blocker

Answer 10

• postural hypotension
• dizzy
• syncope
  especiallt post first dose

Question 11

Relative CI to alpha blockers

Answer 11

postural hypotension

Question 12

if patient also on BB and AB what should they do

Answer 12

first day dont take BB

Question 13

what dose do u start doxazosin at

Answer 13

1mg per day and increase at 1-2 weekly intervals

Question 14

what is doxazosin licensed for

Answer 14

• BPH and HTN

Question 15

what is tamsulosin licensed for

Answer 15

• BPH

- GIVEN 400MCG DAILY

Question 16

when should patients take doxazosin

Answer 16

• Bedtime