DM Flashcards
1
Q
dpp4 NAMES
A
sitagliptin, linagliptin, saxagliptin
2
Q
dpp4 MOA
A
T2DM with metformin wheere uncontrolled by single agent or metformin is CI
3
Q
MOA dpp4
A
prevent incretin degreddation and increase plasma conc of active forms.
action is glucose dependant
4
Q
MOA DPP4
A
- GI upset
- headache
- nasopharyngitis
- peripheral oedema
- hypoglycaemia if in combo with sulphonylurea and insulin
- acute pancreatitis
5
Q
CI DPP4
A
- Hypersenstivity
- t1dm
- ketoacidosis
- pregnancy
- breastfeeding
- elderly - caution >80yr
- hx pancreatitis -caution
- moderate to severe renal imapirment - lower dose
6
Q
what forms can you get dpp4 in
A
- alone
- fixed dose with metformin
7
Q
target hba1c if on dpp4
A
- if monotherapy <48
- dual = <53
8
Q
insulin indications
A
- T1DM or bad T2DM
- IV Diabetic emergencies
- hyperkalaemia
9
Q
MOA insulin
A
like endogenous. drives k+ into cells
10
Q
different types fo insulin
A
short acting - actrapid. intermediate actin - humulin
logn actin - lantus/levemir
-rapid - novorapid
- biphasic; rapid and intermediate acting = novomix
11
Q
SE insulin
A
hypoglycaemia, lipohypertrophy
12
Q
CI insulin
A
caution in renal impaired. as clearance reduced
13
Q
metofrmin indications
A
T2DM
14
Q
MOA metformin
A
- lowers BG by reducing hepatic glucose output and increasing glucose uptake and utilisation by skeletal muscle. works by increasing AMP kinase - does the above. also get small weight loss
15
Q
SE metformin
A
- GI upset
- lactic acidosis
