dementia Flashcards
1
Q
name acetylcholinesterase-i
A
donepezil
rivastigmine
2
Q
ach-i indications
A
- alzheimers
- dementia in parkinsons
3
Q
MOA ach-i
A
- increase acha vilable so better cognition.
4
Q
SE ach-i
A
n+ve+D
- if asthma and copd, increased sx
- peptic ulcer
- bleeds in ulcers
- bradycardia
- heart block
- hallucinations
- change in behaviour
- EPS and Neuroleptic malignant syndrome
5
Q
Relative CI ach-i
A
asthma
copd
peptic ulcer
rivastigmine worsens tremor in PD
6
Q
CI to ach-i
A
- heart block
- sick sinus syndrome
7
Q
interactions of ach=i
A
- NSAIDs and steroids with ach-i = peptic ulcer
- with antipsychotics = NMS
- if with BB - bradycardia/heart block
8
Q
starting dose donepezil
A
5mg
9
Q
starting dose rivastigmine
A
1.5mg 12hrly
10
Q
which ach-i is available as patch
A
rivastigmine
11
Q
when should you monitor a patient on ach-i
A
2-4 weeks for SE
- 3months for efficacy
12
Q
what ach-i gives vivid dreams
A
donepezil
