bone mets Flashcards
1
Q
bisphosphonates indications
A
- alendronic acid for fragility fractures due to osteoporosis
- pamidronate and zolidronic acid = treatment for severe hyperca of malignancy after IV rehydration
+ myeloma and bone mets due to breast ca - 1st line in pagets
2
Q
MOA bisphosphonates
A
- inhibits actions of osteoclasts, inhibit activity and promote apoptosis = reduction in bone loss and increased bone mass
3
Q
SE bisphosphonates
A
- oesophagitis and hypophosphotaemia
- osteonecrosis fo the jaw
- atypical femoral fracture
4
Q
CI bisphosphonates
A
- severe renal impairment
- hypocalcaemia
- upper GI disorders; cannot give orally
5
Q
relative CI to bisphosphonates
A
- smokers
- dental disease
due to risk of osteonecrosis of jaw
6
Q
what should u not take bisphosphonates with and why
A
- milk, antacids, iron salts
- they bind caclium, there absoption is reduced if taken with above
7
Q
name some bisphosphonates
A
alendronic acid, pamidronate, zoledronic acid
8
Q
dose of alendronic acid for osteoporosis
A
70mg
9
Q
with bisphosphonates when do u start to see changes in calcium elvel if treating hypercalcaemia, and when does it peak
A
- 3-4 days
- 7- 10 days
10
Q
when to take bisphosphonates
A
- 30mins pre breakfast
