herpes

Question 1

antiviral drugs names

Answer 1

aciclovir, ganciclovir

Question 2

antivirals Indications

Answer 2

• rx of acute herpesvirus infections including herpes simplex e.g. cold sores, genital ulcers, encephalitis. and VZV
• Supression of recurrent herpes simplex attacks where occuring at frequency of 6 + / year

Question 3

antivirals MOA

Answer 3

• herpes virus = DNA virus. this needs Herpes specific DNA polymerase for virus to replicate.
• inhibits herpes specific DNA polymerase

Question 4

SE antivirals

Answer 4

• headaches
• dizziness
• GI disturbances
• skin rash

IV - phlebitis. it is very water insoluble so at high conc can precipitate in renal tubules = AKI. reduce risk by good hydration and slowing infusion

Question 5

relative CI aciclovir

Answer 5

• pregnancy
• breastfeed but if severe infections must give
• dose reduction in severe renal impairment

Question 6

aciclovir oral and genital herpes dose and mode

Answer 6

• topical 5x/day or 200mg five times a day. start in prodromal phase.
• recurrent infections = supressive treatmnet (400ng 12hrly)

Question 7

aciclovir for herpes simplex encephalitis

Answer 7

• 10-15ml/kg 8hrly IV

- 14-21 days

Question 8

minimum time of infusion for IV aciclovir

Answer 8

1hr