IBD general Flashcards
1
Q
peak age
A
20-30
2
Q
aetiology
A
impaired mucosal immunity - NOD2 gene
environmental trigger
3
Q
what does the NOD 2 gene usually do
A
contribute to normal mucosal defence
4
Q
treatment guidelines
A
- 5ASA (not crohns)
- steroid
- IS
- anti -TNF
- surgery
5
Q
5-ASA
A
mesalazine
6
Q
steroid
A
oral prednisolone or budesonide
7
Q
IS
A
azathrioprine or methotrexate
8
Q
anti-TNF
A
infliximab
9
Q
name 2 Aminosalicylates
A
sulfasalazine and mesalazine
10
Q
what effect does mesalazine have on the risk of colon cancer
A
reduces the risk
11
Q
Sulfasalazine AE
A
rashes, arthralgia
12
Q
Mesalazine AE
A
weight gain
diabetes
hypertension
diarrhoea and idiosyncratic nephritis
13
Q
glucocorticoids AE
A
avascular necrosis and osteoporosis
14
Q
what musnt you prescribe with azathioprine
A
allupurinol
15
Q
Azathioprine onset of action
A
16 weeks
