IBD general

Question 1

peak age

Answer 1

20-30

Question 2

aetiology

Answer 2

impaired mucosal immunity - NOD2 gene

environmental trigger

Question 3

what does the NOD 2 gene usually do

Answer 3

contribute to normal mucosal defence

Question 4

treatment guidelines

Answer 4

1. 5ASA (not crohns)
2. steroid
3. IS
4. anti -TNF
5. surgery

Question 5

5-ASA

Answer 5

mesalazine

Question 6

steroid

Answer 6

oral prednisolone or budesonide

Question 7

IS

Answer 7

azathrioprine or methotrexate

Question 8

anti-TNF

Answer 8

infliximab

Question 9

name 2 Aminosalicylates

Answer 9

sulfasalazine and mesalazine

Question 10

what effect does mesalazine have on the risk of colon cancer

Answer 10

reduces the risk

Question 11

Sulfasalazine AE

Answer 11

rashes, arthralgia

Question 12

Mesalazine AE

Answer 12

weight gain
diabetes
hypertension
diarrhoea and idiosyncratic nephritis

Question 13

glucocorticoids AE

Answer 13

avascular necrosis and osteoporosis

Question 14

what musnt you prescribe with azathioprine

Answer 14

allupurinol

Question 15

Azathioprine onset of action

Answer 15

16 weeks

Question 16

Azathioprine AE

Answer 16

lymphoma/skin cancer
pancreatitis
hepatotoxicity

Question 17

Ciclosprorin AE

Answer 17

renal toxicity

Question 18

how do you give adalimumab

Answer 18

SC injection

Question 19

how do u give infliximab

Answer 19

IV injection

Question 20

symptoms seen in both UC and Crohns

Answer 20

erythema nodosum
pyoderma gangrenosum
diarrhoea
arthritis