hepatocellular carcinoma Flashcards
men or women more common?
men
what is it associated with
cirrhosis causing disease
HBV, HCV
alcohol
aflatoxin
explain symptoms
as most patients with HCC also have cirrhosis the HCC is often masked by cirrhosis symptoms
symptoms
asymptomatic
weight loss, RUQ pain, mass, fatigue, dec appetite, acute liver failure
O/E
stigmata of cirrhosis
hard enlarged RUQ mass
liver bruit
labs
alpha fetoprotein raised
cirrhosis
treatment
transplant resection local ablation chemoembolisation - TACE systemic treatment
what is TACE
chemo injected into hepatic artery
what systemic treatment used
sorafenib
fibrolamellar carcinoma people
young women
what is fibrolamellar carcinoma not related to
CIRRHOSIS
what is the AFP like in fibrolamellar carcinoma
normal
what does CT show with fibrolamellar carcinoma
stellate scar with radial septa
what is the prognosis of fibrolamellar carcinoma like compared to HCC
better than HCC if completely resected before metastasis has occurred
treatment for fibrolamellar carcinoma
surgical resection or transplantation
