hepatitis Flashcards
Hep A type of virus
RNA
Hep A spread and peak age
faecal oral or shellfish, childhood
most common cause of Hep in returned travellers
Hep A acute or chronic?
acute, no chronic!
rare cause of Hep A
EBV
lab Hep A
clotted blood for serology
rise in hep A IgM - recent infection, IgG detectable for life
Hep A control
hygiene vaccine
Hep B type of virus
DNA
Hep B spread
sex, blood, mother to child
Hep B infectivity and chronic vs hep C
hep B - very infectious and less likely to become chronic
hep C - most patients chronic carriers, less infectious
rare cause of hep B
yellow fever virus
Hep B
HbsAg
infectious and infected
Hep B
antiHbsAg
vaccinated and recovered
Hep B
HbeAg
highly infective
Hep B
antiHbcAg
past infection
Hep B DNA titre
high in highly infectious patients
control of Hep B
minimise exposure
vaccination
antiHbe Hep B
low infectivity
Hep C virus type
RNA flavivirus
spread of Hep C
similar to hep B but less so by sex
incubation period of Hep c
4-6weeks
incubation period of Hep B
4-6 months
vaccine to hep C?
no
out come of Hep C
chronic hepatitis or cirrhosis
lab of Hep C
first test for Ab to Hep C
then PCR for Hep C RNA to see if active or past infection
which Hep exacerbates Hep B
D
Hep E spread
facial oral, zoonosis, person to person in IC/tropics
Hep E rare cause
cytomegalovirus
most common Hep in UK
E
vaccine for Hep E?
no
treatment for acute hepatitis
NO ANTIVIRALS
monitor for encephalopathy or resolution
public health
immunise contacts
treatment for chronic hepatitis
antivirals and interferon alpha
hepatocellular cancer awareness or screening
how is interferon alpha available
peginterferon
list antivirals used
-fovir
adefovir, entecavir, tenofovir
contraindication to antivirals
liver cancer
how does one use peginterferon in Hep C patients
with ribavirin and protease inhibitor
peginterferon side effects
flu like
what is peginterferon not very successful in
Hep D
what is Hep D
incomplete RNA virus - needs HPB for its assembly
what does ribavarin have a side effect of
anaemia
hep C rare cause
herpes simplex virus
what is possible with peginterferon and antivirals
a sustained cure is possible with peginterferon
antivirals only suppress
treatment of Hep B
peginterferon alone or antiviral therapy
