hepatitis

Question 1

Hep A type of virus

Answer 1

RNA

Question 2

Hep A spread and peak age

Answer 2

faecal oral or shellfish, childhood

most common cause of Hep in returned travellers

Question 3

Hep A acute or chronic?

Answer 3

acute, no chronic!

Question 4

rare cause of Hep A

Answer 4

EBV

Question 5

lab Hep A

Answer 5

clotted blood for serology

rise in hep A IgM - recent infection, IgG detectable for life

Question 6

Hep A control

Answer 6

hygiene vaccine

Question 7

Hep B type of virus

Answer 7

DNA

Question 8

Hep B spread

Answer 8

sex, blood, mother to child

Question 9

Hep B infectivity and chronic vs hep C

Answer 9

hep B - very infectious and less likely to become chronic

hep C - most patients chronic carriers, less infectious

Question 10

rare cause of hep B

Answer 10

yellow fever virus

Question 11

Hep B

HbsAg

Answer 11

infectious and infected

Question 12

Hep B

antiHbsAg

Answer 12

vaccinated and recovered

Question 13

Hep B

HbeAg

Answer 13

highly infective

Question 14

Hep B

antiHbcAg

Answer 14

past infection

Question 15

Hep B DNA titre

Answer 15

high in highly infectious patients

Question 16

control of Hep B

Answer 16

minimise exposure

vaccination

Question 17

antiHbe Hep B

Answer 17

low infectivity

Question 18

Hep C virus type

Answer 18

RNA flavivirus

Question 19

spread of Hep C

Answer 19

similar to hep B but less so by sex

Question 20

incubation period of Hep c

Answer 20

4-6weeks

Question 21

incubation period of Hep B

Answer 21

4-6 months

Question 22

vaccine to hep C?

Answer 22

no

Question 23

out come of Hep C

Answer 23

chronic hepatitis or cirrhosis

Question 24

lab of Hep C

Answer 24

first test for Ab to Hep C

then PCR for Hep C RNA to see if active or past infection

Question 25

which Hep exacerbates Hep B

Answer 25

D

Question 26

Hep E spread

Answer 26

facial oral, zoonosis, person to person in IC/tropics

Question 27

Hep E rare cause

Answer 27

cytomegalovirus

Question 28

most common Hep in UK

Answer 28

E

Question 29

vaccine for Hep E?

Answer 29

no

Question 30

treatment for acute hepatitis

Answer 30

NO ANTIVIRALS
monitor for encephalopathy or resolution
public health
immunise contacts

Question 31

treatment for chronic hepatitis

Answer 31

antivirals and interferon alpha

hepatocellular cancer awareness or screening

Question 32

how is interferon alpha available

Answer 32

peginterferon

Question 33

list antivirals used

Answer 33

-fovir

adefovir, entecavir, tenofovir

Question 34

contraindication to antivirals

Answer 34

liver cancer

Question 35

how does one use peginterferon in Hep C patients

Answer 35

with ribavirin and protease inhibitor

Question 36

peginterferon side effects

Answer 36

flu like

Question 37

what is peginterferon not very successful in

Answer 37

Hep D

Question 38

what is Hep D

Answer 38

incomplete RNA virus - needs HPB for its assembly

Question 39

what does ribavarin have a side effect of

Answer 39

anaemia

Question 40

hep C rare cause

Answer 40

herpes simplex virus

Question 41

what is possible with peginterferon and antivirals

Answer 41

a sustained cure is possible with peginterferon

antivirals only suppress

Question 42

treatment of Hep B

Answer 42

peginterferon alone or antiviral therapy