Crohns

Question 1

mural or transmural

Answer 1

transmural

Question 2

which part of the GI tract does it effect

Answer 2

any - skip lesions

Question 3

what is the nature of the disease

Answer 3

relapsing and remitting

Question 4

histology

Answer 4

cobblestone appearance

knife like lesions- rose thorn ulcer

non caseating granuloma

goblet cell

Question 5

what T cells are involved

Answer 5

Th1

Question 6

what happens to the wall

Answer 6

thickened and fat wrapping can lead to stricture formation

Question 7

most common sites affected

Answer 7

small bowel, terminal ileum and perianal disease

Question 8

what effect does smoking have

Answer 8

aggregates it

Question 9

symptoms

Answer 9

non bloody diarrhoea

weight loss

abdominal pain

clubbing

Question 10

classical patient

Answer 10

thin and malnourished

Question 11

diagnosis

Answer 11

endoscopy and barium follow through/enema

Question 12

what will endoscopy show

Answer 12

cobblestoning and rose thorn ulcers

Question 13

complications

Answer 13

Fistula

Amylodisos

Malabsorption - B12 and anaemia

small bowel obstruction

Question 14

what is amyloidosis

Answer 14

accumulations deposits of abnormally folded protein

Question 15

surgery

Answer 15

DOESNT CURE

resection stricturoplasty

Question 16

what can repeated resection the gut case

Answer 16

short gut syndrome

Question 17

what are the indications for surgery

Answer 17

stenosis causing obstruction

complications

failure of medical therapy

fistula

acute or chronic bleeding

failure for child to grow despite treatment