Gastrointestinal and Hepatobiliary Diseases Flashcards
What is a syndrome?
Collection of disease
any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms
Disease
autoimmune disease of the salivary, lacrimal glands, and synovial membrane
Sjogren syndrome
Sjogren triad
Xerostomia
Keratoconjunctivitis sicca
Rheumatoid arthritis
Other name of sjogren syndrome
Sicca syndrome
Cell responsible for an autoimmune disease
T-cell
Main cause of an autoimmune disease
Stress
Organs affected in sicca syndrome
Salivary gland
Eyes
Joint
What are the signs and symptoms of Reiter’s syndrome?
Arthritis
Conjunctivitis
Urethritis
What are the signs and symptoms of Mikulicz syndrome?
Conjunctivitis
Xerostomia
Difference between Reiter’s and Sicca syndrome?
Sicca affects: Eyes, Joints, Salivary gland while
Reiter’s affects: Eyes, Joints and Urethra
True or false: Sjogren’s syndrome is also associated with mikulicz syndrome.
True
Syndromes associated with sicca syndrome
Reiter’s syndrome
Mikulicz syndrome
A benign tumor of the PAROTID GLAND
Warthin’s tumor
Other name of warthin’s tumor
Papillary cystadenoma lymphomatosum
Major salivary gland common to diseases
Parotid gland
Most common salivary gland tumor
Mixed tumor
Other name of mixed tumor
Pleomorphic adenoma
most common malignancy of major salivary glands
Mucoepidermoid carcinoma
most common malignancy of minor salivary gland
Adenoid cystic carcinoma
Histologic feature of adenoid cystic carcinoma
Cheese-like
Characterized by lacerations of the esophagus
Mallory-weiss syndrome
Manifestation of mallory-weiss syndrome
Melena
Black stool in the blood is due to?
Degradation of blood by acid
Bleeding below the stomach would manifest?
Hematochezia
Melena-
hematochezia-
Melena- black stool
Hematochezia- red stool
T/F: Melena and Hematochezia solidifies together with stool
False- does not solidify
syndrome where there is ruptured esophagus that causes massive GI hemorrhage
Boerhaave syndrome
Sign and symptoms of boerhaave syndrome
Sever vomiting
Straining
A reflux of acid content due to histamine released of the stomach.
Gastroesophageal reflux disease
GERD is always associated with?
Barrett’s esophagus
Barrette’s esophagus is what type of cellular adaptation?
Metaplasia
Change of epithelial cells in barrett’s esophagus
Squamous to columnar
Barrett’s esophagus left untreated leads to?
Adenocarcinoma
Oral manifestation of GERD
Erosion on the lingual surface of the molars
Drugs for GERD
Antihistamine (H2 BLOCKER, cimetidine)
Antacids
Proton-pump inihibitor
Complication of Barrett’s esophagus
Hemorrhage
Stricture
Adenocarcinoma
Ulcerations
Most sever complication of barrett’s esophagus
Adenocarcinoma
Erosion on the lingual of incisors
Bulimia nervosa
caused by early activation of pancreatic enzyme resulting in auto-digestion
Acute pancreatitis
Acute pancreatitis undergoes what type of necrosis?
Enzymatic fat necrosis
Blood test result of Acute pancreatitis
Increased serum amylase and lipase
Decreased calcium
Enzyme that dominates in acute pancreatitis
Lipase
It is characterized by yellowness of tissues due to excess serum Bilirubin in the blood.
Jaundice
Other name for Jaundice
Icterus
Jaundice in brain
Kernicterus
Specific art of brain where jaundice occurs
Basal ganglia o brain
True or false. Bilirubin crosses the placenta
True
Jaundice in newborn affects?
Brain
Causes of jaundice
Hepatocellular
Hemolytic
Obstructive
Pancreatic carcinoma
Bilirubin conjugate with what element of blood
RBC
Other name of hemolytic in jaundice
Hemolytic anemia
Other name of obstructive jaundie
Cholelith
gives pigment to bruises
Biliverdin
a pigment accumulation in kupffer cell which is a sign of liver injury.
CEROID
It is characterized by excessive scarring and nodule formation
cirrhosis
Causes of cirrhosis
Alcoholism Viral hepatitis Hemochromatosis Wilson's disease Dubin-johnson's disease
Most common cause of cirrhosis
aLcoholism
Liver cirrhosis due to excessive iron in the liver
Hematochromatosis
Liver cirrhosis due to excessive copper in the liver
Wilson’s disease
pathognomonic sign of wilson’s disease
Keyser-fleischer ring
Keyser-fleischer ring
Borderof the iris is color green due to excess copper
Liver cirrhosis due to excessive melanin
Dubin-johnson’s disease
Other name for Dubin-johnson’s disease
Black liver disease
Blood tests needed for cirrhosis
Increased AST or SGOT
Increased ALT or SGPT
AST stands for?
ALT stands for?
aspartate trans-aminoferase
alanine trans-aminoferase
SGOT stands for?
SGPT stands for?
Serum glutamic oxaloacetic transaminoferase
Serum glutamate pyruvate transaminoferase
Most common viral hepatitis
Hepatitis A
Route of transmission of Hepatitis a
Oral-fecal/ oral-anal
GI tract
Causative agent for Hepatitis A
Picornavirus
Most common blood-borne
Hep B
Causative agent for Hep B
Hepadnavirus
Sterlization process that could kill Hep B
Moist-heat
Duration of Medication for Hep B
Lifetime intake
Most difficult virus to eradicate
Hepadnavirus
most common hepatitis in blood transfusion
Hep C
causative agent for Hep C
Flavivirus
Most difficult to diagnose Hepatitis
Hepatitis C
Hepatitis with slowest progress
Hepatitis C
Every hepatitis have a vaccine except?
Hepatitis C
Recurrent of HepB
Hepatitis D
Hepatitis associatedwith ACUTE LIVER FAILURE
Hepatitis E
Sterilizing agent used in the hospital to eliminate Hep B
Sodium hypochlorite
Causative agent for Hep D
Deltavirus
Causative agent for Hep E
Calicivirus
the marker of Hepa B
HbSAg
Indications that the virus is multiplying in the body
HbEAg and HbSAg
Carrier of Hep B
HbSAg and anti-HbSAg
Indicates chronic hepatitis and patient is contraindicated for blood transfusion
HbCAg
An autosomal dominant characterized by dark, freckle-like spots that appear on the skin, lips and oral mucosa.
Peutz-Jeghers syndrome
Other name for peutz jeghers syndrome
Hereditary Intestinal Polyposis Syndrome
What is a polyp?
Inflamed blood vessel
Autosomal means?
Affects the 1st to 22nd paired chromosome
X-linked means?
Affects the 23rd paired chromosome
Requires both genes of the parents to affect the child
Recessive
Requires at leastone gene to affect the child
Dominant
A chronic inflammatory bowel disease that results to cobblestone appearance
Chron’s disease
A congenital disease that affects COLON
Hirschprung’s disease
An autoimmune disease that results to intolerance of gluten proteins present in wheat, barley and rye.
Celiac disease
An autoimmune disease affecting children that results to intolerance of gluten proteins present in wheat, barley and rye.
Gee-herter’s disease
Oral manifestation of Celiac disease
Glossitis