Blood-Lymphatics Flashcards
There is decreased number of platelets
Thrombocytopenia
The most common type of bleeding disorder
Thrombocytopenia
Amount of platelets to be diagnosed of thrombocytopenia
50,000 platelets
Platelet deficiency is associated with?
Idiopathic thrombocytopenic telangiectasia
Acute myelogenous leukemia
Aplastic anemia
organ defective in aplastic anemia
Bone marrow
An X-linked recessive disorder of the blood
Hemophilia
A deficiency in Clotting factor VIII
Hemophilia A
Most common hemophilia in males and children
Hemophilia A
Laboratory test for Hemophilia A
PTT
Deficiency in clotting factor IX
Hemophilia B
other name for hemophilia A
Classic hemophilia
other name for hemophilia B
Christmas disease
Clotting time and bleeding time of Hemophilia A
Increased Clotting time
Normal bleeding time
Clotting time and bleeding time of Hemophilia B
Normal clotting time
Normal bleeding time
Deficiency in clotting factor XI
Hemophilia C
What is the test that differentiates hemophilia A to B
PTT test
Caused by malabsorption of FATS which results to Decreased in blood clotting factor II, VII, IX, X
Vitamin K deficiency
Laboratory test for Vitamin K deficiency
Prolonged PT
Dental concern in patient with Vit. K deficiency
Profuse bleeding
Deficiency in vWF
Von willebrand disease
most common hereditary bleeding disorder
Von willebrand disease
bleeding time of Von Willebrand
Increased bleeding time
Features of von willebrand disease
Qualitative platelet defect
vWF allows adhesion of platelets to collagen
it affects platelet plug and coagulation cascade
autosomal dominant
characterized by uncontrolled proliferation of an abnormal monoclonal cell of either MYELOID or Lymphocytic
Leukemia
Dental concern in patients with anemia
Profuse bleeding due to Thrombocytopenia
most severe type of leukemia
Acute lymphocytic leukemia (ALL)
ALL commonly affects?
CHILDREN
Histologic cell in in ALL
Null cells
What are null cells?
WBC without substance
Lymphocytic anemia affects what WBC?
Lymphocyte
Most common type of leukemia in adult
Acute Myeloid Leukemia
Histologic cell found in AML
Aeur rods may be observed in blastcells
Monoclonal means?
cell produced by another cell
WBC affected by myeloid leukemia
Either BASOPHILS, NEUTROPHILS,EOSINOPHILS and monocyte
WBC most commonly affecetd by cancer?
Monocyte
Leukemia with poorest prognosis
Acute lymphocytic leukemia
Least malignant leukemia
Chronic lymphocytic leukemia
Histologic cell in CLL
Smudge cells
Leukemia associated with philadelphia chromosome
Chronic myeloid leukemia
What is philadelphia chromosome?
Translocation of chromosome 9 with 22
Rarest type of leukemia
Aleukemic leukemia
What is the most common drug used to treat leukemia?
Cyclosporine
Cyclosporine is a what kind of drug?
Immunosuppressant by suppressing bone marrow
Disease characterized by enlarged lymph nodes
LYMPHOMA
Lymphoma that mainly affects T-cells
Hodgkin’s Lymphoma
Causative agent for HL
Reed-stenberg
Other name for reed-sternberg
Dorothy-reed
Most common type of HL
Nodular sclerosis
Type of HL shows Pautrier Abscess
Mycosis Fungoides
two types of HL
Nodular sclerosis
Mycosis fungoides
Other name for Mycosis Fungoides
Alibert-bazin syndrome
Lymphoma that affects B-cells
Non-Hodgkin’s lymphoma
Causative agent of non-hodgkin’s lymphoma
EBV
Signs and symptoms of Non-hodkin’s lymphoma
night sweats, malaise, fatigue, and solid tumors
Type of lymphoma that is 95% common in AFRICAN nations.
Burkitt’s lymphoma
One complication of AIDS
EBV
Burkitt’s lymphoma is associated with what leukemia?
Acute lymphocytic anemia
Difference between ALL and Burkitt’s lymphoma
Burkitt’s affects lymph nodes
ALL does not affect lymph nodes
What is the radiographic appearance of burkitt’s lymphoma?
Moth-eaten
What is the histologic appearance of burkitt’s lymphoma?
Starry-sky effect
Disease with abnormal proliferation of Monoclonal plasma cells
Multiple myeloma
Other name for multiplemyeloma
Plasma myeloma
Presence of Bence-Jones proteins in urinalysis
Multiple myeloma
CBC of multiple myeloma
Decreased RBC, WBC, and platelets except PLASMA cell
Radiographic appearance of multiple myeloma
Multiple-punched out
Multiple myeloma mostly affects?
Skull
Disease with a very low levels of antibdies results from a failure of B-cells to differentiate
Bruton’s Agammaglobulinemia
Disease with a decreased number of antibodies present due to slow antibody production.
Transient hypogammaglobulinemia
Disease deficient in B-cell
Transient hypogammaglobulinemia
Disease deficient in T-cells resulting from a failure of the third and fourth branchial pouches to develop normally.
Digeorge syndrome
Digeorge syndrome is the absence of what chromosome?
22
Organs affected in Digeorge syndrome
Thymus gland and parathyroid glands
Oral manifestation of Digeorge syndrome
Palata cleft
Most severe immunodeficiency disease due to absence of both b-cells and T-cells in the body.
Severe combined immunodeficiency syndrome
Treatment in Severe combined immunodeficiency syndrome
Bone marrow transplant