Gastroenterology 9 - Primary Sclerosing Cholangitis

Question 1

define PSC

Answer 1

intraheptic / extrahepatic bile ducts get strictured and scarred

cause bile flow problems out of the liver + then inflammation of ducts

Question 2

4 key risk factors for PSC

Answer 2

ulcerative colitis
male
30-40 years old
FH

Question 3

5 presenting features in PSC

Answer 3

jaundice 
chronic RUQ pain
itch 
fatigue 
enlarged liver

Question 4

3 key investigations in diagnosing PSC

Answer 4

LFTs (cholestatic - ALP up)
autoAbs (p-ANCA)
MRCP (MRI scan of ducts/panc)

Question 5

4 associations with PSC

Answer 5

acute bacterial cholangitis 
cholangiocarcinoma 
colorectal cancer
cirrhosis 
fat soluble vitamin deficiency

Question 6

4 aspects of treatment for PSC

Answer 6

ERCP stenting
UDA
colestyramine
monitor compolications x 3 (cholangioca, cirrhosis, varcies)

can cure with liver transplant