Endocrinology 9 - Acromegaly

Question 1

2 causes acromegaly

Answer 1

pituitary adenoma
ectopic secretion (lung, pancreas)

Question 2

8 presenting features of acromegaly

Answer 2

headache
bitemporal hemianopia

frontal bossing
large nose
macroglossia
large hands, feet
prognathism (jaw)
arthritis

Question 3

4 organ dysfunction examples with acromegaly

Answer 3

hypertrophic heart
hypertension
type 2 diabetes
colorectal cancer

Question 4

treatment for acromegaly (1 surgical, 3 medical )

Answer 4

trans-sphenoidal removal / ectopic cancer removal

pegvisomant GH antagonist subcut
ocreotide (somstat analogue)
bromocriptine (dopamine agonist blocks GH release)