Gastroenterology 17 - Coeliac Disease Flashcards
2 main autoAbs in coeliac and where do they attack
anti tissue transglutaminase anti TTG
anti endomysial anti EMA
attack the jejunum
effect on intestine of coeliac
atrophy of villi
crypt hypertrophy
7 aspects of coeliac presentation
more commonly in children but can be any age
FTT diarrhoea fatigue weight loss mouth ulcers anaemia from deficiency dermatitis herpetiformis
dermatitis herpetiformis
itchy blistering skin rash on abdo assoc with coeliac
rare presentation aspect of coeliac
neuro symptoms
peripheral neuropathy, cerebellar ataxia, epilepsy
what must always be tested in a new presentation of type 1 diabetes/
COELIAC
genetic assoc with coeliac
HLA DQ2
what is a key thing to remember for coeliac Ab testing?
must also test total IgA levels as if they are deficient the test may be falsely negative
final confirmation of coeliac
biopsy during colonoscopy confirms villous atrophy and crypt hypertrophy
6 complications of untreated coeliac
vitamin deficiency anaemia osteoporosis ulcerative jejunitis EATL non-Hodgkin lymphoma
treatment for coeliac
lifelong gluten free
can monitor Abs for progress
