G protein coupled receptors Flashcards
name the two types of g protein coupled receptors
Muscarinic (aka M)
Adrenoreceptors (aka A+B)
If Beta 1 had an agonist
Heart rate would speed up and force and contraction would increase
If Beta 2 had an agonist
the bronchi relax (and decreases mucus production)
if Beta 3 had an agonist
thermogenesis of skeletal muscle
if Alpha one had an agonist
vasoconstriction of blood vessels
if Alpha 2 had an agonist
relaxation of the GI Tract
adrenoreceptors are bound an activated by what neurotransmitters
ADRENALINE AND NORADRENALINE
B2 - Salbutamol and Salmeterol
B1and 2 - Partial agonist - Pindolol
if M1 had an agonist
increase stomach acid production
If M2 had an agonist
decrease Heart rate and force
if M3 had an agonist
constricts bronchi
increases mucus production
Talk through the process of M1
M1- Gaq- stimulates phospholipase C- increases stomach acid production
Talk through the process of M2
M2- Gai- Inhibits Adenyl Cyclase - opens K+ channels- Increase HR and force
Talk through the process of M3
M3- Gaq - stimulates Phospholipase C - constricts bronchi
Talk through the process of A1
A1 - Gaq- stimulates phospholipase C - constricts Blood vessels
Talk through the process of A2
A2 - Gai - Inhibits adenyl cyclase - relaxation of the GI tract
