90R. Pathology of pulmonary neoplasia Flashcards
what is the leading cause of cancer related deaths
lung cancer
what are the 2 primary types
benign (rare)
malignant (common)
aside from primary types of lung cancer, what is the other type
metastatic (common)
what is the microanatomy of lung cancer - what structures does it involve
conducting airways and gas exchange compartments.
Bronchi (with cartilage and glands) and bronchioles (no cartilage and elastic support)
what are the risk factors of lung cancer
smoking, asbestos, nickel, chromates, radiation, pollution and genetics
what are local effects in the presentation of lung malignancy
airway obstruction- Pneumonia, chest wall invasion- pain, ulceration - haemoptysis
where can lung malignancy metastasize to
spread to lymph nodes, bones, liver , brain
what are the systemic effects of lung cancer
weight loss, ectopic hormone production (e.g. PTH, ACTH)
what is the pathogenesis of lung cancer
changes in pulmonary epithelium due to risk factors/mutations (smoking etc)
what is included in the histology of lung cancer
adenocarcinoma, sqaumous cell carcinoma, small cell carcinoma, large cell neuroendocrine carcinoma
what is pathological diagnosis of lung cancer based on
morphology and immunohistochemistry
